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The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells

Author

Listed:
  • Agata Jabłońska-Trypuć

    (Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology, 15-351 Białystok, Poland)

  • Urszula Wydro

    (Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology, 15-351 Białystok, Poland)

  • Lluis Serra-Majem

    (Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain)

  • Elżbieta Wołejko

    (Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology, 15-351 Białystok, Poland)

  • Andrzej Butarewicz

    (Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology, 15-351 Białystok, Poland)

Abstract

Bifenox and Dichlobenil belong to the commonly used in Poland in agriculture group of herbicides and their residues are often detected in the environment. They are poorly known regarding their possible carcinogenic and antibacterial effect at the cellular level. Therefore, we decided to study their activity in bacterial strains Aliivibrio fisheri, E. coli, P. aeruginosa, and C. albicans (yeast) and human cancer ZR-75-1 cells. Compounds under study exhibit stimulatory effect on analyzed bacterial strains. The study performed on mammalian cells better reflects the influence of environmental pollutants on human organism, therefore we evaluated the effect of herbicides on ZR-75-1 cells. Cells viability, apoptosis and selected oxidative stress parameters in ZR-75-1 cells were investigated. Both analyzed substances exhibit stimulatory effects on analyzed parameters, however they do not stimulate apoptosis which correlate positively with the induction of oxidative stress. Bifenox and Dichlobenil enhance oxidative stress parameters by the generation of high levels of ROS, which can lead to their adaptation and resistance to the standard treatment regimen.

Suggested Citation

  • Agata Jabłońska-Trypuć & Urszula Wydro & Lluis Serra-Majem & Elżbieta Wołejko & Andrzej Butarewicz, 2019. "The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells," IJERPH, MDPI, vol. 16(21), pages 1-19, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:21:p:4137-:d:280733
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