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The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

Author

Listed:
  • Khaled Greish

    (Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain
    Nanomedicine Research Unite, Princess Al—Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Abdulelah Abdullah Alqahtani

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Abdulla Falah Alotaibi

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Ahmed Mohamed Abdulla

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Aysha Tariq Bukelly

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Fanar Mohammed Alsobyani

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Ghazi Hamad Alharbi

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Israa Saeed Alkiyumi

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Majed Mutlaq Aldawish

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Turki Fahad Alshahrani

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Valeria Pittalà

    (Department of Drug Sciences, University of Catania, 95125 Catania, Italy)

  • Sebastien Taurin

    (Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain
    Nanomedicine Research Unite, Princess Al—Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

  • Amer Kamal

    (Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain)

Abstract

Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe use of AgNPs could pose a real threat, not only to public health but also to economic growth in many industries. In this paper, we tested the effect of AgNPs on memory, learning, social behaviour and motor function of BALB/C mice. Outcomes of the present study suggested an impairment of these functions in AgNPs treated groups. Overall, obtained data support the evidence that the systemic exposure to AgNPs may result in alteration of the cerebral cognition and warrants further consideration on the impact of the AgNPs on human health with respect to their potential neurotoxicity.

Suggested Citation

  • Khaled Greish & Abdulelah Abdullah Alqahtani & Abdulla Falah Alotaibi & Ahmed Mohamed Abdulla & Aysha Tariq Bukelly & Fanar Mohammed Alsobyani & Ghazi Hamad Alharbi & Israa Saeed Alkiyumi & Majed Mutl, 2019. "The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice," IJERPH, MDPI, vol. 16(1), pages 1-10, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:148-:d:195573
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