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A Global View to HBV Chronic Infection: Evolving Strategies for Diagnosis, Treatment and Prevention in Immunocompetent Individuals

Author

Listed:
  • Laura Ambra Nicolini

    (Infectious Diseases Unit, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy)

  • Andrea Orsi

    (Hygiene Unit, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
    Department of Health Sciences, University of Genoa, 16132 Genoa, Italy)

  • Paola Tatarelli

    (UOC Malattie Infettive, Santa Maria delle Croci, 48121 Ravenna, Italy)

  • Claudio Viscoli

    (Infectious Diseases Unit, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
    Department of Health Sciences, University of Genoa, 16132 Genoa, Italy)

  • Giancarlo Icardi

    (Hygiene Unit, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
    Department of Health Sciences, University of Genoa, 16132 Genoa, Italy)

  • Laura Sticchi

    (Hygiene Unit, IRCCS Policlinico San Martino Hospital, 16132 Genoa, Italy
    Department of Health Sciences, University of Genoa, 16132 Genoa, Italy)

Abstract

Hepatitis B Virus (HBV) is a significant public health challenge. Around 250 million people live with chronic HBV infection. With a global approach to this issue, we focus on new perspective in diagnosis, management and prevention of HBV chronic infection. Precise diagnosis of HBV status is crucial to guide patient management. Although available drugs reduce the risk of liver disease progression, they are not able to definitely eradicate HBV, and new therapeutic options are urgently needed. Thus, prevention of HBV infection is still the most effective strategy to achieve the control of the disease. Key aspects of prevention programs include surveillance of viral hepatitis, screening programs and immunization strategies. In spite of the high success rate of licensed HBV vaccines, a need for improved vaccine persists, especially in order to provide coverage of current non-responders.

Suggested Citation

  • Laura Ambra Nicolini & Andrea Orsi & Paola Tatarelli & Claudio Viscoli & Giancarlo Icardi & Laura Sticchi, 2019. "A Global View to HBV Chronic Infection: Evolving Strategies for Diagnosis, Treatment and Prevention in Immunocompetent Individuals," IJERPH, MDPI, vol. 16(18), pages 1-17, September.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:18:p:3307-:d:265412
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    References listed on IDEAS

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    1. Hui Jin & Zhaoying Tan & Xuefeng Zhang & Bei Wang & Yueyuan Zhao & Pei Liu, 2015. "Comparison of Accelerated and Standard Hepatitis B Vaccination Schedules in High-Risk Healthy Adults: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-16, July.
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