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Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial

Author

Listed:
  • Maria Elisabetta Baldassarre

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Antonio Di Mauro

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Margherita Fanelli

    (Medical Statistics, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy)

  • Manuela Capozza

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Jennifer L. Wampler

    (Mead Johnson Nutrition, Department of Medical Affairs, Evansville, IN 47721, USA)

  • Timothy Cooper

    (Mead Johnson Nutrition, Department of Medical Affairs, Evansville, IN 47721, USA)

  • Nicola Laforgia

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy)

Abstract

Background: This study was carried out to evaluate enteral feeding advancement and tolerance in preterm infants receiving one of two marketed formulas: intact protein preterm formula (IPF) or extensively hydrolyzed formula (EHF) for the first 14 feeding days. Methods: Primary outcome was days to full enteral feeding (≥140 mL/kg/day). Per protocol analyses included the following: all participants who met study entrance criteria and completed study feeding (primary) and those who received ≥75% enteral intake from study formula (subset). Mothers were encouraged to provide their breast milk. Results: Of the 65 enrolled (IPF: n = 32; EHF: n = 33), 60 completed study feeding per protocol (IPF: n = 30; EHF: n = 30), 37 (62%) received predominantly breast milk, and 23 (38%) received ≥75% study formula intake (IPF: n = 11; EHF: n = 12). No group differences were detected in tolerance measures. No necrotizing enterocolitis (NEC) was reported. Median time to achievement of full enteral feeding was significantly shorter for the IPF vs. EHF group (day 10 vs. 14, p < 0.05) (subset analysis). Mean enteral intake significantly increased by day 14 for the IPF group ( p < 0.05), reflecting group divergence as achieved feeding volumes increased. Conclusions: Results suggest shorter time to full enteral feeding and higher feeding volume achieved by study end in preterm infants receiving intact protein preterm formula versus extensively hydrolyzed formula.

Suggested Citation

  • Maria Elisabetta Baldassarre & Antonio Di Mauro & Margherita Fanelli & Manuela Capozza & Jennifer L. Wampler & Timothy Cooper & Nicola Laforgia, 2019. "Shorter Time to Full Preterm Feeding Using Intact Protein Formula: A Randomized Controlled Trial," IJERPH, MDPI, vol. 16(16), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:16:p:2911-:d:257485
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    Cited by:

    1. Annalisa Guarini & Miguel Pérez Pereira & Anneloes van Baar & Alessandra Sansavini, 2021. "Special Issue: Preterm Birth: Research, Intervention and Developmental Outcomes," IJERPH, MDPI, vol. 18(6), pages 1-4, March.

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