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An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls

Author

Listed:
  • Akifumi Eguchi

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan)

  • Shino Nishizawa-Jotaki

    (Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 263-8522, Japan
    Teijin Limited, Kasumigaseki Common Gate West Tower, 2-1, Kasumigaseki 3-chome, Chiyoda-ku, Tokyo 100-0013, Japan)

  • Hiromi Tanabe

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan)

  • Bahityar Rahmutulla

    (Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 263-8522, Japan)

  • Masahiro Watanabe

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan)

  • Hidenobu Miyaso

    (Department of Anatomy, Tokyo Medical University, Shinjuku-ku Shinjuku 6-1-1, Tokyo 160-8402, Japan)

  • Emiko Todaka

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 263-8522, Japan)

  • Kenichi Sakurai

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan)

  • Atsushi Kaneda

    (Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 263-8522, Japan)

  • Chisato Mori

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 263-8522, Japan)

Abstract

Maternal exposure to polychlorinated biphenyls (PCBs) results in abnormal fetal development, possibly because of epigenetic alterations. However, the association between PCB levels in cord serum with fetal DNA methylation status in cord tissue is unclear. This study aims to identify alterations in DNA methylation in cord tissue potentially associated with PCB levels in cord serum from a birth cohort in Chiba, Japan (male neonates = 32, female neonates = 43). Methylation array analysis identified five sites for female neonates (cg09878117, cg06154002, cg06289566, cg12838902, cg01083397) and one site for male neonates (cg13368805) that demonstrated a change in the methylation degree. This result was validated by pyrosequencing analysis, showing that cg06154002 ( tudor domain containing 9 : TDRD9 ) in cord tissue from female neonates is significantly correlated with total PCB levels in cord serum. These results indicate that exposure to PCBs may alter TDRD9 methylation levels, although this hypothesis requires further validation using data obtained from female neonates. However, since the present cohort is small, further studies with larger cohorts are required to obtain more data on the effects of PCB exposure and to identify corresponding biomarkers.

Suggested Citation

  • Akifumi Eguchi & Shino Nishizawa-Jotaki & Hiromi Tanabe & Bahityar Rahmutulla & Masahiro Watanabe & Hidenobu Miyaso & Emiko Todaka & Kenichi Sakurai & Atsushi Kaneda & Chisato Mori, 2019. "An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls," IJERPH, MDPI, vol. 16(15), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2786-:d:254691
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    References listed on IDEAS

    as
    1. Kenichi Sakurai & Keiko Shioda & Akifumi Eguchi & Masahiro Watanabe & Hidenori Miyaso & Chisato Mori & Toshi Shioda, 2019. "DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effec," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-22, May.
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