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Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Author

Listed:
  • Dezhong Yu

    (School of Chemical and Environmental Engineering, Wuhan Institute of Technology, LiuFang Campus, No.206, Guanggu 1st road, Wuhan 430205, China)

  • Xiaofang Liu

    (School of Chemical and Environmental Engineering, Wuhan Institute of Technology, LiuFang Campus, No.206, Guanggu 1st road, Wuhan 430205, China
    Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

  • Xiao Liu

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

  • Wencheng Cao

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

  • Xiaotian Zhang

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

  • Haoyuan Tian

    (Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, China)

  • Jin Wang

    (Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, China)

  • Nan Xiong

    (College of Chemistry and Materials Science, South Central University for Nationalities, #182 Minzu Avenue, Wuhan 430074, China)

  • Sheng Wen

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

  • Yongning Wu

    (The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (CFSA) and China National Center for Food Safety Risk Assessment, #7 Panjiayuan Nanli, Beijing 100021, China)

  • Xin Sun

    (Key Laboratory of Chemical Safety and Health, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, #27 Nan Wei Road, Beijing 100050, China)

  • Yan Zhou

    (Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, #6 Zhuo Daoquan North Road, Wuhan 430079, China)

Abstract

Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs), and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative compounds that may affect fetal growth and infant development. The aim of this study was to determine whether the pregnant women living near a chemical plant in Tianjin had a risk of exposure to dioxins. Concentrations of PCDD/Fs and dl-PCBs in 24 umbilical cord serum samples collected from pregnant women were measured using a high-resolution gas chromatograph with a high-resolution mass spectrometer (HRGC-HRMS) and an isotopic dilution method. The levels of ∑(PCDD/Fs + dl-PCBs) were in the range 476–8307 pg·g −1 lipid, with a mean of 3037 pg·g −1 . The mean World Health Organization toxicity equivalent (WHO-TEQ) for PCDD/Fs and dl-PCBs was 14.0 and 2.14 pg·g −1 lipid, respectively. The PCDD/Fs and dl-PCBs contributed 86.7% and 13.3%, respectively, to the total TEQ. The octa-CDFs and penta-CBs were predominant for the PCDD/Fs and dl-PCBs, accounting for 57.6% and 74.3%, respectively. Several PCDD/F and dl-PCB congeners were highly correlated, such as PCB 105 and PCB 118 (r = 0.982, p < 0.001). Although the results hint at decreasing trends for PCDD/F and dl-PCBs by comparison with a similar study in Tianjin, a total TEQ of 41.7% of study participants had a body burden that exceeded the biomonitoring equivalents for dioxins. It was shown that pregnant women and infants had a health risk of exposure to dioxins.

Suggested Citation

  • Dezhong Yu & Xiaofang Liu & Xiao Liu & Wencheng Cao & Xiaotian Zhang & Haoyuan Tian & Jin Wang & Nan Xiong & Sheng Wen & Yongning Wu & Xin Sun & Yan Zhou, 2019. "Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China," IJERPH, MDPI, vol. 16(12), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:12:p:2178-:d:241388
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    Citations

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    Cited by:

    1. Xiaofang Liu & Wencheng Cao & Xiao Liu & Yan Zhou & Sheng Wen, 2022. "Associations between Maternal Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Serum Concentrations and Pulse Pressure in Early Pregnancy: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(21), pages 1-11, October.
    2. Montse Marquès & Jose L. Domingo, 2019. "Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade," IJERPH, MDPI, vol. 16(19), pages 1-18, September.

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