IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i11p2004-d237419.html
   My bibliography  Save this article

Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential

Author

Listed:
  • Kamil Gill

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Joanna Jakubik

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

  • Aleksandra Rosiak-Gill

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
    VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland)

  • Michał Kups

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
    VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland
    Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland)

  • Mariusz Lukaszuk

    (Healthcare Center Nowe Orlowo, 81-525 Gdynia, Poland
    Invicta Fertility Clinic, 80-850 Gdansk, Poland)

  • Maciej Kurpisz

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Monika Fraczek

    (Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland)

  • Małgorzata Piasecka

    (Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland)

Abstract

Because the assessment of sperm DNA fragmentation (SDF) plays a key role in male fertility, our study was designed to find the relationships between SDF and standard semen parameters. The receiver operating characteristic (ROC) curve showed that 18% SDF is a prognostic parameter for discriminating between men with normal and abnormal standard semen parameters (n = 667). Men with > 18% SDF had significantly lower quality semen, a higher prevalence of abnormal semen characteristics, and a higher odds ratio for abnormal semen parameters compared to men with ≤ 18% SDF. An ROC analysis provided predictive values for age and semen parameters to distinguish between men with SDF > 18% and men with ≤ 18% SDF. SDF was positively correlated with male age and teratozoospermia index but negatively with sperm concentration, total number of spermatozoa, sperm morphology, progressive motility, and vitality. Our study shows that 18% SDF has a predictive value for distinguishing between men with normal and abnormal semen characteristics. Men with >18% SDF have a higher risk for abnormal semen parameters, while age and obtained semen parameters have a predictive value for SDF. There is a relationship between SDF and conventional sperm characteristics, and thus, SDF can be incorporated into male fertility assessment.

Suggested Citation

  • Kamil Gill & Joanna Jakubik & Aleksandra Rosiak-Gill & Michał Kups & Mariusz Lukaszuk & Maciej Kurpisz & Monika Fraczek & Małgorzata Piasecka, 2019. "Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential," IJERPH, MDPI, vol. 16(11), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:11:p:2004-:d:237419
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/11/2004/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/11/2004/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Maartje Cissen & Madelon van Wely & Irma Scholten & Steven Mansell & Jan Peter de Bruin & Ben Willem Mol & Didi Braat & Sjoerd Repping & Geert Hamer, 2016. "Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-23, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kamil Gill & Michal Kups & Patryk Harasny & Tomasz Machalowski & Marta Grabowska & Mariusz Lukaszuk & Marcin Matuszewski & Ewa Duchnik & Monika Fraczek & Maciej Kurpisz & Malgorzata Piasecka, 2021. "The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen," IJERPH, MDPI, vol. 18(11), pages 1-16, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:11:p:2004-:d:237419. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.