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Global Analysis of Transcriptional Expression in Mice Exposed to Intermediate Frequency Magnetic Fields Utilized for Wireless Power Transfer Systems

Author

Listed:
  • Shin Ohtani

    (Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan)

  • Akira Ushiyama

    (Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama 351-0197, Japan)

  • Machiko Maeda

    (Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan)

  • Keiji Wada

    (Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji 192-0397, Japan)

  • Yukihisa Suzuki

    (Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji 192-0397, Japan)

  • Kenji Hattori

    (Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan)

  • Naoki Kunugita

    (Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama 351-0197, Japan)

  • Kazuyuki Ishii

    (Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan)

Abstract

Background: Intermediate frequency magnetic fields (IF-MFs) at around 85 kHz are a component of wireless power transfer systems used for charging electrical vehicles. However, limited data exist on the potential health effects of IF-MFs. We performed a comprehensive analysis of transcriptional expression in mice after IF-MF exposure. Materials and Methods: We developed an IF-MF exposure system to generate a high magnetic flux density (25.3 mT). The system can expose the IF-MF for a mouse whole-body without considering thermal effects. After 10 days (1 h/day) of exposure, a comprehensive expression analysis was performed using microarray data from both the brain and liver. Results: No significant differences in transcriptional expression were detected in the 35,240 probe-sets when controlling the false discovery rate (FDR) under a fold change cutoff >1.5. However, several differential expressions were detected without FDR-adjustment, but these were not confirmed by RT-PCR analysis. Conclusions: To our knowledge, this is the first in vivo study to evaluate the biological effects of IF-MF exposure with an intense magnetic flux density 253 times higher than the occupational restriction level defined by the International Commission on Non-Ionizing Radiation Protection guidelines. However, our findings indicate that transcriptional responses in the living body are not affected under these conditions.

Suggested Citation

  • Shin Ohtani & Akira Ushiyama & Machiko Maeda & Keiji Wada & Yukihisa Suzuki & Kenji Hattori & Naoki Kunugita & Kazuyuki Ishii, 2019. "Global Analysis of Transcriptional Expression in Mice Exposed to Intermediate Frequency Magnetic Fields Utilized for Wireless Power Transfer Systems," IJERPH, MDPI, vol. 16(10), pages 1-8, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:10:p:1851-:d:234224
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    References listed on IDEAS

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    1. Shin Koyama & Eijiro Narita & Naoki Shinohara & Junji Miyakoshi, 2014. "Effect of an Intermediate-Frequency Magnetic Field of 23 kHz at 2 mT on Chemotaxis and Phagocytosis in Neutrophil-Like Differentiated Human HL-60 Cells," IJERPH, MDPI, vol. 11(9), pages 1-11, September.
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