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Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma

Author

Listed:
  • Chih-Jan Ko

    (Department of General Surgery, Changhua Christian Hospital, Changhua 500, Taiwan
    School of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Chia-Jung Li

    (Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan)

  • Meng-Yu Wu

    (Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
    Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan)

  • Pei-Yi Chu

    (School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan
    Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan)

Abstract

Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT , JUK , Wnt , and P53 , and their expression activates several important processes such as cell proliferation, migration, motility, and interaction in the microenvironment. The leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR-5) is a novel biomarker, particularly in stem cells, and is involved in embryogenesis, tumor development, and tumor cell signal transduction. Here, we investigated LGR-5 expression using immunohistochemistry and analyzed the correlation between clinical features and prognosis in patients with hepatocellular carcinoma (HCC). We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups. Thus, the LGR-5 marker is suggested to be a routine biomarker for poor prognosis, thereby providing a platform for anti-LGR-5-targeted therapy in the future.

Suggested Citation

  • Chih-Jan Ko & Chia-Jung Li & Meng-Yu Wu & Pei-Yi Chu, 2019. "Overexpression of LGR-5 as a Predictor of Poor Outcome in Patients with Hepatocellular Carcinoma," IJERPH, MDPI, vol. 16(10), pages 1-9, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:10:p:1836-:d:233765
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    Cited by:

    1. Viera Kupčová & Michaela Fedelešová & Jozef Bulas & Petra Kozmonová & Ladislav Turecký, 2019. "Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD," IJERPH, MDPI, vol. 16(19), pages 1-25, September.

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