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A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis

Author

Listed:
  • Giovanni Sotgiu

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
    Equally contributed.)

  • Narcisa Muresu

    (Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
    Equally contributed.)

  • Marco Dettori

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy)

  • Erica Mura

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy)

  • Andrea Cossu

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy)

  • Maria Dolores Masia

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy)

  • Paola Murgia

    (Intensive Unit Care, “SS Annunziata” Hospital, 07100 Sassari, Italy)

  • Clementina Cocuzza

    (Department of Medicine and Surgery, University of Milano-Bicocca, 20126 Monza, Italy)

  • Enrico Pietro Luigi De Santis

    (Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy)

  • Christian Scarano

    (Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy)

  • Carlo Spanu

    (Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy)

  • Andrea Piana

    (Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy)

Abstract

Listeriosis is a foodborne disease characterized by high hospitalization and fatality rates, especially in vulnerable groups including elderly subjects, pregnant women, etc. We report on the first case of Listeria monocytogenes ST-219 meningo-encephalitis in a woman aged 83 years. An epidemiological and molecular investigation was performed to detect the source of infection and the virulence factors associated with L. monocytogenes invasiveness in this patient. All environmental- and clinical-associated isolates were found to belong to serotype 4b and ST-219 as well as possessing actA, prfA, hlyA , and rrn virulence genes. Antibiotic susceptibility testing also detected resistance to cotrimoxazole, clindamycin, erythromycin, and oxacillin in these isolates. Conventional and molecular surveillance of listeriosis cases, based on the systematic assessment of spatio-temporal trends, virulence genes, and antimicrobial susceptibility testing patterns, are key to preventing and controlling the emergence and spread of L. monocytogenes strains, including hypervirulent clones.

Suggested Citation

  • Giovanni Sotgiu & Narcisa Muresu & Marco Dettori & Erica Mura & Andrea Cossu & Maria Dolores Masia & Paola Murgia & Clementina Cocuzza & Enrico Pietro Luigi De Santis & Christian Scarano & Carlo Spanu, 2018. "A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis," IJERPH, MDPI, vol. 16(1), pages 1-7, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2018:i:1:p:8-:d:192124
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