IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i8p1614-d160828.html
   My bibliography  Save this article

Effects of Bisphenol A and 4- tert -Octylphenol on Embryo Implantation Failure in Mouse

Author

Listed:
  • Dinh Nam Tran

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

  • Eui-Man Jung

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

  • Changhwan Ahn

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

  • Jae-Hwan Lee

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

  • Yeong-Min Yoo

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

  • Eui-Bae Jeung

    (Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea)

Abstract

Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for the embryo implantation process. Exposure to endocrine-disrupting chemicals (EDs) during early gestation results in disruption of intrauterine implantation and uterine reception, leading to implantation failure. In this study, ovarian estrogen (E2), bisphenol A (BPA), or 4- tert -octylphenol (OP), with or without ICI 182,780 (ICI) were injected subcutaneously from gestation day 1 to gestation day 3 post-coitus. The expression levels of the calcium transport genes were assessed in maternal uteri and implantation sites. The number of implantation sites was significantly low in the OP group, and implantation sites were absent in the E2, ICI and EDs + ICI groups. There were different calcium transient transport channel expression levels in uterus and implantation site samples. The levels of TRPV5 and TRPV6 gene expression were significantly increased by EDs with/without ICI treatment in utero. Meanwhile, TRPV5 and TRPV6 gene expression were significantly lower in implantation sites samples. NCX1 and PMCA1 mRNA levels were significantly decreased by OP and BPA in the implantation site samples. Compared to vehicle treatment in the uterus, both the MUC1 mRNA and protein levels were markedly high in all but the BPA group. Taken together, these results suggest that both BPA and OP can impair embryo implantation through alteration of calcium transport gene expressions and by affecting uterine receptivity.

Suggested Citation

  • Dinh Nam Tran & Eui-Man Jung & Changhwan Ahn & Jae-Hwan Lee & Yeong-Min Yoo & Eui-Bae Jeung, 2018. "Effects of Bisphenol A and 4- tert -Octylphenol on Embryo Implantation Failure in Mouse," IJERPH, MDPI, vol. 15(8), pages 1-16, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1614-:d:160828
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/8/1614/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/8/1614/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jae-Hwan Lee & Changhwan Ahn & Hee Young Kang & Eui-Ju Hong & Sang-Hwan Hyun & Kyung-Chul Choi & Eui-Bae Jeung, 2016. "Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas," IJERPH, MDPI, vol. 13(10), pages 1-13, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Donatella Caserta & Flavia Costanzi & Maria Paola De Marco & Luisa Di Benedetto & Eleonora Matteucci & Chiara Assorgi & Maria Clara Pacilli & Aris Raad Besharat & Filippo Bellati & Ilary Ruscito, 2021. "Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies," IJERPH, MDPI, vol. 18(13), pages 1-21, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1614-:d:160828. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.