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2-Naphthol Levels and Allergic Disorders in Children

Author

Listed:
  • Tien-Jen Lin

    (Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
    Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 333, Taiwan
    Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei 110, Taiwan)

  • Yueliang Leon Guo

    (National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 100, Taiwan)

  • Jiin-Chyr Hsu

    (Department of Internal Medicine, Taipei Hospital, Ministry of Health and Welfare, No. 127, Su-Yuan Road, Hsin-Chuang Dist., Taipei 242, Taiwan
    Yuanpei University of Medical Technology, Hsinchu 300, Taiwan)

  • I-Jen Wang

    (Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, No. 127, Su-Yuan Road, Hsin-Chuang Dist., Taipei 242, Taiwan
    College of Public Health, China Medical University, Taichung 404, Taiwan
    School of Medicine, National Yang-Ming University, Taipei 112, Taiwan)

Abstract

Background : The measurement of polycyclic aromatic hydrocarbons (PAH) in ambient air is quite difficult to perform. Using urine biomarkers of PAH such as 2- naphthol is one approach to this problem. This study explored the association between urine 2- naphthol levels and allergic diseases. The associations between 2- naphthol levels and oxidative stress biomarkers for the possible disease pathogenesis were also investigated. Method : A total of 453 kindergarten children from the (Childhood Environment and Allergic Diseases Study) CEAS cohort with urine samples were recruited. Urine 2- naphthol levels were measured by high-performance liquid chromatography mass spectrometry (HPLC-MS/MS) and markers of oxidative stress (8OHdG) were measured by enzyme-linked immunosorbent assays (ELISA). Information on environmental risk factors and allergic diseases were also collected. The association between 2- naphthol levels, 8OHdG levels, IgE, and allergic diseases were evaluated by multivariate linear regression and logistic regression. Results : Levels of 2- naphthol were positively correlated with 8OHdG levels. A one ln-unit increase in the 2- naphthol level was positively associated to 8OHdG levels (per ln-unit: β = 100.61, p < 0.001). When dividing 2- naphthol levels into quartiles, asthma was significantly associated with 2- naphthol levels at a concentration of >1.60 ng/mL (adjusted OR: 3.14, 95% CI 1.34–7.35). Conclusion : Urine 2- naphthol levels are associated with markers of oxidative stress and the risk of allergic diseases in young children.

Suggested Citation

  • Tien-Jen Lin & Yueliang Leon Guo & Jiin-Chyr Hsu & I-Jen Wang, 2018. "2-Naphthol Levels and Allergic Disorders in Children," IJERPH, MDPI, vol. 15(7), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1449-:d:157061
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