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Exposure to Environmental Contaminants and Lung Function in Adolescents—Is There a Link?

Author

Listed:
  • Marike M. Leijs

    (Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
    Ecobaby Foundation, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands
    Department of Dermatology and Allergology, RTWH University Aachen, Pauwelstrasse 30, 52074 Aachen, Germany)

  • Janna G. Koppe

    (Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
    Ecobaby Foundation, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands)

  • Kees Olie

    (IBED/ESPM, University of Amsterdam, 1090 GE Amsterdam, The Netherlands)

  • Pim De Voogt

    (IBED/ESPM, University of Amsterdam, 1090 GE Amsterdam, The Netherlands
    KWR Watercycle Research Institute, P.O. Box 1072, 3430 BB Nieuwegein, The Netherlands)

  • Wim M. C. Van Aalderen

    (Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
    Shared last authorship.)

  • Gavin W. Ten Tusscher

    (Department of Paediatrics and Neonatology, Westfriesgasthuis, Maelsonstraat 3, 1624 NP Hoorn, The Netherlands
    Shared last authorship.)

Abstract

Dioxins (polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDF)), polychlorinated biphenyls (PCBs), and brominated flame retardants (BDEs) are well known toxic environmental contaminants. Their possible role in the incidence of respiratory disease is not yet well understood. Previous studies showed a negative effect on lung function in relation to prenatal and lactational dioxin exposure in pre-pubertal children. Effects of BDE exposure on the lung function have not previously been evaluated. As part of a longitudinal cohort study, the effects of perinatal dioxin (PCDD/F) exposure and serum PCDD/F, dl-PCB, and BDE levels on lung function in adolescents were assessed using spirometry, a body box, and diffusion measurements. Thirty-three children (born between 1986 and 1991) consented to the current follow-up study. Prenatal, lactational, and current dioxin, PCB, and BDE concentrations were determined using GC-MS. No relationship was seen between prenatal and lactational dioxin exposure, nor with current PCB body burden, and lung function. Indications of increasing airway obstruction were seen in relation to increasing current BDE exposure. This is a novel finding and certainly warrants further research.

Suggested Citation

  • Marike M. Leijs & Janna G. Koppe & Kees Olie & Pim De Voogt & Wim M. C. Van Aalderen & Gavin W. Ten Tusscher, 2018. "Exposure to Environmental Contaminants and Lung Function in Adolescents—Is There a Link?," IJERPH, MDPI, vol. 15(7), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1352-:d:154844
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