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Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study

Author

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  • Anton A. Kovalenko

    (Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway
    International School of Public Health, Northern State Medical University, 163000 Arkhangelsk, Russia)

  • Erik Eik Anda

    (Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway)

  • Jon Øyvind Odland

    (Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway)

  • Evert Nieboer

    (Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, L9H 6C6 ON, Canada)

  • Tormod Brenn

    (Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway)

  • Alexandra Krettek

    (Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway
    Department of Biomedicine and Public Health, School of Health and Education, University of Skövde, 54128 Skövde, Sweden
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 41390 Gothenburg, Sweden)

Abstract

Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88].

Suggested Citation

  • Anton A. Kovalenko & Erik Eik Anda & Jon Øyvind Odland & Evert Nieboer & Tormod Brenn & Alexandra Krettek, 2018. "Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study," IJERPH, MDPI, vol. 15(7), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1320-:d:154117
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    References listed on IDEAS

    as
    1. Olga A. Kharkova & Andrej M. Grjibovski & Alexandra Krettek & Evert Nieboer & Jon Ø. Odland, 2017. "Effect of Smoking Behavior before and during Pregnancy on Selected Birth Outcomes among Singleton Full-Term Pregnancy: A Murmansk County Birth Registry Study," IJERPH, MDPI, vol. 14(8), pages 1-11, August.
    2. Botto, L.D. & Robert-Gnansia, E. & Siffel, C. & Harris, J. & Borman, B. & Mastroiacovo, P., 2006. "Fostering international collaboration in birth defects research and prevention: A perspective from the International Clearinghouse for Birth Defects Surveillance and Research," American Journal of Public Health, American Public Health Association, vol. 96(5), pages 774-780.
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    Cited by:

    1. Valery P. Chashchin & Sergei Gorbanev & Yngvar Thomassen & Evert Nieboer & Dag G. Ellingsen & Sergei Syurin & Alexandr Nikanov & Max Chashchin & Jon Øyvind Odland, 2020. "Occupational Medicine and Environmental Health in the Border Areas of Euro-Arctic Barents Region: A Review of 30-Year Russian–Norwegian Research Collaboration Outcomes," IJERPH, MDPI, vol. 17(11), pages 1-8, May.

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