IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i6p1077-d149110.html
   My bibliography  Save this article

Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis

Author

Listed:
  • Cheryl S. Pirozzi

    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA)

  • Daniel L. Mendoza

    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Department of Atmospheric Sciences, University of Utah, Salt Lake City, UT 84112, USA)

  • Yizhe Xu

    (Department of Population Health Science, University of Utah, Salt Lake City, UT 84132, USA)

  • Yue Zhang

    (Divisions of Epidemiology and Public Health, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA)

  • Mary Beth Scholand

    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA)

  • Robert P. Baughman

    (Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45219, USA)

Abstract

This study aimed to determine if short-term exposure to particulate matter (PM 2.5 ) and ozone (O 3 ) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM 2.5 and O 3 estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough questionnaire (LCQ), Saint George Respiratory Questionnaire (SGRQ), and King’s Sarcoidosis Questionnaire (KSQ)) using generalized linear mixed effect models. PM 2.5 level averaged over 14 days was associated with lower KSQ general health status (score change −6.60 per interquartile range (IQR) PM 2.5 increase). PM 2.5 level averaged over 10 and 14 days was associated with lower KSQ lung specific health status (score change −6.93 and −6.91, respectively). PM 2.5 levels were not associated with FEV 1 , FVC, episodes of FEV 1 decline > 10%, or respiratory symptoms measured by SGRQ or LCQ. Ozone exposure was not associated with any health outcomes. In this small cohort of patients with fibrotic sarcoidosis, PM 2.5 exposure was associated with increased severity of respiratory and quality of life symptoms.

Suggested Citation

  • Cheryl S. Pirozzi & Daniel L. Mendoza & Yizhe Xu & Yue Zhang & Mary Beth Scholand & Robert P. Baughman, 2018. "Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1077-:d:149110
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/6/1077/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/6/1077/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Angelina L. DeMarco & Rebecca Hardenbrook & Jeff Rose & Daniel L. Mendoza, 2020. "Air Pollution-Related Health Impacts on Individuals Experiencing Homelessness: Environmental Justice and Health Vulnerability in Salt Lake County, Utah," IJERPH, MDPI, vol. 17(22), pages 1-16, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1077-:d:149110. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.