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Stress-Induced and Diabetic Hyperglycemia Associated with Higher Mortality among Intensive Care Unit Trauma Patients: Cross-Sectional Analysis of the Propensity Score-Matched Population

Author

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  • Meng-Wei Chang

    (Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)

  • Chun-Ying Huang

    (Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)

  • Hang-Tsung Liu

    (Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)

  • Yi-Chun Chen

    (Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)

  • Ching-Hua Hsieh

    (Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan)

Abstract

Background: This study was designed to measure the effect of stress-induced hyperglycemia (SIH) and diabetic hyperglycemia (DH) versus non-diabetic normoglycemia (NDN) on the outcomes of trauma patients in the intensive care unit (ICU). Methods: Diabetes mellitus (DM) was determined based on patient history and/or a hemoglobin A1c (HbA1c) level of ≥6.5% at admission. The patients who had serum glucose levels of ≥200 mg/dL in the absence or presence of DM were assigned into the groups SIH and DH, respectively. Diabetic normoglycemia (DN) and NDN were determined based on serum glucose levels of <200 mg/dL in patients with and without DM, respectively. Patients with burn injury or incomplete data were excluded. Detailed data of trauma patients in the ICU of a Level-I trauma center from 1 January 2009 to 31 December 2016 were retrieved from the database of the Trauma Registry System. These patients were classified into four exclusive groups, including NDN ( n = 1745), DN ( n = 306), SIH ( n = 225) and DH ( n = 206). The Pearson chi-square test was used to compare categorical data between groups. Continuous variables were compared using one-way analysis of variance along with the Games–Howell post hoc test. To decrease the confounding effect of the differences in sex and age, preexisting comorbidities and injury severity score (ISS) among different groups of patients, 1:1 ratio propensity score-matched cohorts were assigned using the NCSS software. The effect of hyperglycemia on the outcomes of patients with and without DM was assessed with a logistic regression analysis. Results: Among those selected propensity score-matched patient cohorts, the patients with SIH and DH had a 3.88-fold (95% CI, 2.13–7.06; p < 0.001) and 1.83-fold (95% CI, 1.00–3.34; p = 0.048) higher mortality, respectively, than those with NDN. Moreover, the patients in the SIH group (10.0 vs. 7.4 days; p = 0.005) and those in the DH group (10.1 vs. 7.4 days; p = 0.006) who were admitted to the ICU had a significantly longer length of stay than those in the NDN group. In addition, the SIH group had a 2.13-fold (95% CI, 1.04–4.36; p = 0.038) higher adjusted odds ratio for mortality than the DH group. Conclusions: This study revealed significantly worse outcomes in terms of mortality among patients with SIH and DH who were admitted to the ICU after controlling for sex and age, preexisting comorbidities and ISS. In addition, patients who had SIH presented significantly higher adjusted odds for mortality than those DH patients. These results suggest that hyperglycemia is detrimental in patients with or without DM who were admitted to the ICU, and there is a different pathophysiological mechanisms behind the SIH and DH.

Suggested Citation

  • Meng-Wei Chang & Chun-Ying Huang & Hang-Tsung Liu & Yi-Chun Chen & Ching-Hua Hsieh, 2018. "Stress-Induced and Diabetic Hyperglycemia Associated with Higher Mortality among Intensive Care Unit Trauma Patients: Cross-Sectional Analysis of the Propensity Score-Matched Population," IJERPH, MDPI, vol. 15(5), pages 1-10, May.
  • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:992-:d:146362
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    References listed on IDEAS

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    1. Cheng-Shyuan Rau & Shao-Chun Wu & Yi-Chun Chen & Peng-Chen Chien & Hsiao-Yun Hsieh & Pao-Jen Kuo & Ching-Hua Hsieh, 2017. "Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia, Is Associated with Higher Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: Analysis of a Propensity Score-M," IJERPH, MDPI, vol. 14(11), pages 1-10, November.
    2. Cheng-Shyuan Rau & Shao-Chun Wu & Yi-Chun Chen & Peng-Chen Chien & Hsiao-Yun Hsieh & Pao-Jen Kuo & Ching-Hua Hsieh, 2017. "Higher Mortality in Trauma Patients Is Associated with Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia: A Cross-Sectional Analysis Based on a Propensity-Score Matching Approach," IJERPH, MDPI, vol. 14(10), pages 1-10, September.
    3. Cheng-Shyuan Rau & Shao-Chun Wu & Yi-Chun Chen & Peng-Chen Chien & Hsiao-Yun Hsieh & Pao-Jen Kuo & Ching-Hua Hsieh, 2017. "Stress-Induced Hyperglycemia in Diabetes: A Cross-Sectional Analysis to Explore the Definition Based on the Trauma Registry Data," IJERPH, MDPI, vol. 14(12), pages 1-11, December.
    4. Cheng-Shyuan Rau & Shao-Chun Wu & Yi-Chun Chen & Peng-Chen Chien & Hsiao-Yun Hsieh & Pao-Jen Kuo & Ching-Hua Hsieh, 2017. "Mortality Rate Associated with Admission Hyperglycemia in Traumatic Femoral Fracture Patients Is Greater Than Non-Diabetic Normoglycemic Patients but Not Diabetic Normoglycemic Patients," IJERPH, MDPI, vol. 15(1), pages 1-10, December.
    5. Michael Brownlee, 2001. "Biochemistry and molecular cell biology of diabetic complications," Nature, Nature, vol. 414(6865), pages 813-820, December.
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    1. Yu-Chin Tsai & Shao-Chun Wu & Ting-Min Hsieh & Hang-Tsung Liu & Chun-Ying Huang & Sheng-En Chou & Wei-Ti Su & Shiun-Yuan Hsu & Ching-Hua Hsieh, 2021. "Reply to Comment on Tsai, Y.-C., et al. Association of Stress-Induced Hyperglycemia and Diabetic Hyperglycemia with Mortality in Patients with Traumatic Brain Injury: Analysis of a Propensity Score-Ma," IJERPH, MDPI, vol. 18(5), pages 1-2, March.

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