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Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

Author

Listed:
  • Diana Cabrera

    (School of Food and Nutrition, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
    Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand)

  • Marlena Kruger

    (School of Food and Nutrition, Massey University, Tennent Drive, Palmerston North 4442, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand)

  • Frances M. Wolber

    (Centre for Metabolic Health Research, Massey University, Tennent Drive, Palmerston North 4442, New Zealand)

  • Nicole C. Roy

    (Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    High-Value Nutrition National Science Challenge, Auckland 1142, New Zealand)

  • John J. Totman

    (A*Star-NUS Clinical Imaging Research Centre, Singapore 117599, Singapore)

  • Christiani Jeyakumar Henry

    (A*Star-NUS Clinical Nutrition Research Centre, Singapore 117599, Singapore)

  • David Cameron-Smith

    (Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    The Liggins Institute, The University of Auckland, Auckland 1142, New Zealand)

  • Karl Fraser

    (Food Nutrition & Health Team, Food & Bio-Based Products Group, AgResearch Grasslands, Palmerston North 4442, New Zealand
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    High-Value Nutrition National Science Challenge, Auckland 1142, New Zealand)

Abstract

The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model. Plasma concentrations of eight glycerophospholipid, glycerolipid, and sphingolipid species were significantly lower in menopausal women with low BMD but higher in two glycerophospholipid species (phosphatidylinositol and phosphatidic acid). Further, this study found no significant differences in plasma amino acid metabolites. However, trends for lower 4-aminobutyric acid, turanose, proline, aminopropionitrile, threonine, and methionine were found in women with low BMD. This pilot study identified associations between lipid metabolism and femoral neck BMD in SC women. Further studies are required on larger populations for evaluating the bone health effect of these compounds and their usefulness as clinical biomarkers for osteoporosis prediction in women.

Suggested Citation

  • Diana Cabrera & Marlena Kruger & Frances M. Wolber & Nicole C. Roy & John J. Totman & Christiani Jeyakumar Henry & David Cameron-Smith & Karl Fraser, 2018. "Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study," IJERPH, MDPI, vol. 15(5), pages 1-18, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:1045-:d:148408
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    Cited by:

    1. Jerilynn C. Prior, 2018. "Innovations in Women’s Bone Health—Appreciating Important “Bone Variables” Besides Estrogen," IJERPH, MDPI, vol. 15(9), pages 1-4, September.

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