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Adult Premenopausal Bone Health Related to Reproductive Characteristics—Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaM os )

Author

Listed:
  • Azita Goshtasebi

    (Centre for Menstrual Cycle and Ovulation Research; University of British Columbia, Vancouver, BC V5Z 1M9, Canada)

  • Claudie Berger

    (Canadian Multicentre Osteoporosis Study, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3S5, Canada)

  • Susan I. Barr

    (Centre for Menstrual Cycle and Ovulation Research; University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC V6T 1Z4, Canada)

  • Christopher S. Kovacs

    (Medicine (Endocrinology and Metabolism), Obstetrics & Gynecology, and BioMedical Sciences, Memorial University of Newfoundland, St. John’s, NL A1B 3V6, Canada)

  • Tanveer Towheed

    (Medicine and Public Health, Queens University, Kingston, ON, K7L 3N6 Canada)

  • K. Shawn Davison

    (A Priori Medical Sciences Inc., Victoria, BC V8R 3E3 Canada)

  • Jerilynn C. Prior

    (Centre for Menstrual Cycle and Ovulation Research; University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Department of Medicine, Division of Endocrinology and Metabolism, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    BC Women’s Health Research Institute, Vancouver, BC V6H 2N9, Canada)

Abstract

Amenorrhea is important for women’s bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM os ) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures. This study describes the reproductive characteristics of 1532 women aged 30–60 years. BMD relationships with reproductive and other variables were described in the 499 menstruating women. Mean menarche age was 12.8 years, 96% of women were parous and 95% had used combined hormonal contraceptives (CHC). Infertility was reported by 9%, androgen excess by 13%, amenorrhea by 8% and nulliparity by 4%. LS BMD was negatively associated with amenorrhea and androgen excess and positively related to current BMI and height. A later age at menarche negatively related to FN BMD. BMI and height were strongly related to BMD at all sites. Prevalent fragility fractures were significantly associated with quartiles of both LS and TH BMD.

Suggested Citation

  • Azita Goshtasebi & Claudie Berger & Susan I. Barr & Christopher S. Kovacs & Tanveer Towheed & K. Shawn Davison & Jerilynn C. Prior, 2018. "Adult Premenopausal Bone Health Related to Reproductive Characteristics—Population-Based Data from the Canadian Multicentre Osteoporosis Study (CaM os )," IJERPH, MDPI, vol. 15(5), pages 1-14, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:1023-:d:147752
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    Cited by:

    1. Jerilynn C. Prior, 2018. "Innovations in Women’s Bone Health—Appreciating Important “Bone Variables” Besides Estrogen," IJERPH, MDPI, vol. 15(9), pages 1-4, September.

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