IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i5p1018-d147601.html
   My bibliography  Save this article

Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length

Author

Listed:
  • Shirin Kalyan

    (Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
    Division of Endocrinology; Centre for Menstrual Cycle and Ovulation Research, BC Centre for the Canadian Multicentre Osteoporosis Study, University of British Columbia, Vancouver, BC V5Z 1M9, Canada)

  • Neora Pick

    (Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
    Department of Medicine, Division of Infectious Disease, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada
    BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada)

  • Alice Mai

    (Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada)

  • Melanie C. M. Murray

    (Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
    Department of Medicine, Division of Infectious Disease, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada
    BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada)

  • Kristen Kidson

    (Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada)

  • Jackson Chu

    (Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada)

  • Arianne Y. K. Albert

    (BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada)

  • Hélène C. F. Côté

    (BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada
    Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada)

  • Evelyn J. Maan

    (Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada)

  • Azita Goshtasebi

    (Division of Endocrinology; Centre for Menstrual Cycle and Ovulation Research, BC Centre for the Canadian Multicentre Osteoporosis Study, University of British Columbia, Vancouver, BC V5Z 1M9, Canada)

  • Deborah M. Money

    (Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
    BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC V6Z 2K8, Canada)

  • Jerilynn C. Prior

    (Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
    Division of Endocrinology; Centre for Menstrual Cycle and Ovulation Research, BC Centre for the Canadian Multicentre Osteoporosis Study, University of British Columbia, Vancouver, BC V5Z 1M9, Canada)

Abstract

With advances in combination antiretroviral therapy (cART), people living with HIV are now surviving to experience aging. Evidence suggests that individuals living with HIV are at greater risk for low bone mineral density (BMD), osteoporosis, and fractures. Better understanding of the pathophysiology of bone health in women living with HIV (WLWH) is important for treatment strategies. The goal of this study was to explore new biological factors linked to low BMD in WLWH. Standardized BMD measures of WLWH were compared to reference values from an unselected population of women from the same geographical region of the same age range. Linear regression analysis was used to assess relationships among health-related characteristics, cellular aging (measured by leukocyte telomere length; LTL), cART, and BMD of WLWH. WLWH ( n = 73; mean age 43 ± 9 years) had lower BMD Z -scores at the lumbar spine (LS) (mean difference = −0.39, p < 0.001) and total hip (TH) (−0.29, p = 0.012) relative to controls ( n = 290). WLWH between 50 and 60 years ( n = 17) had lower Z -scores at the LS ( p = 0.008) and TH ( p = 0.027) compared to controls ( n = 167). Among WLWH, LS BMD was significantly associated with LTL (R 2 = 0.09, p = 0.009) and BMI (R 2 = 0.06, p = 0.042). Spinal BMD was adversely affected in WLWH. Reduction of LTL was strongly associated with lower BMD and may relate to its pathophysiology and premature aging in WLWH.

Suggested Citation

  • Shirin Kalyan & Neora Pick & Alice Mai & Melanie C. M. Murray & Kristen Kidson & Jackson Chu & Arianne Y. K. Albert & Hélène C. F. Côté & Evelyn J. Maan & Azita Goshtasebi & Deborah M. Money & Jerilyn, 2018. "Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length," IJERPH, MDPI, vol. 15(5), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:1018-:d:147601
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/5/1018/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/5/1018/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jerilynn C. Prior, 2018. "Innovations in Women’s Bone Health—Appreciating Important “Bone Variables” Besides Estrogen," IJERPH, MDPI, vol. 15(9), pages 1-4, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:1018-:d:147601. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.