IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i4p684-d139719.html
   My bibliography  Save this article

Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans

Author

Listed:
  • María Cecilia García-Espiñeira

    (Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, University of Cartagena, Zaragocilla Campus, Cartagena 130015, Colombia)

  • Lesly Patricia Tejeda-Benítez

    (Biological, Toxicological and Environmental Sciences Research Group, School of Medicine, University of Cartagena, Zaragocilla Campus, Cartagena 130015, Colombia)

  • Jesus Olivero-Verbel

    (Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, University of Cartagena, Zaragocilla Campus, Cartagena 130015, Colombia)

Abstract

Bisphenol A (BPA) is a ubiquitous plasticizer which is absorbed by ingestion and dermal contact; propyl paraben (PPB) inhibits the microbiome and extends the shelf life of many personal care products, whereas triclosan (TCS) is commonly found in antiseptics, disinfectants, or additives. In this work, Caenorhabditis elegans was used as a biological model to assess the toxic effects of BPA, PPB, and TCS. The wild type strain, Bristol N2, was used in bioassays with the endpoints of lethality, growth, and reproduction; green fluorescent protein (GFP) transgenic strains with the hsp-3 , hsp-4 , hsp-16.2 , hsp-70 , sod-1 , sod-4 , cyp-35A4 , cyp-29A2 , and skn-1 genes were evaluated for their mRNA expression through fluorescence measurement; and quick Oil Red O (q ORO) was utilized to stain lipid deposits. Lethality was concentration-dependent, while TCS and PPB showed more toxicity than BPA. BPA augmented worm length, while PPB reduced it. All toxicants moderately increased the width and the width–length ratio. BPA and PPB promoted reproduction, in contrast to TCS, which diminished it. All toxicants affected the mRNA expression of genes related to cellular stress, control of reactive oxygen species, and nuclear receptor activation. Lipid accumulation occurred in exposed worms. In conclusion, BPA, PPB, and TCS alter the physiology of growth, lipid accumulation, and reproduction in C. elegans , most likely through oxidative stress mechanisms.

Suggested Citation

  • María Cecilia García-Espiñeira & Lesly Patricia Tejeda-Benítez & Jesus Olivero-Verbel, 2018. "Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans," IJERPH, MDPI, vol. 15(4), pages 1-16, April.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:4:p:684-:d:139719
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/4/684/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/4/684/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jae-Hwan Lee & Myeongho Lee & Changhwan Ahn & Hee Young Kang & Dinh Nam Tran & Eui-Bae Jeung, 2017. "Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model," IJERPH, MDPI, vol. 14(2), pages 1-13, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yun Ma & Yujing Li & Xiaohong Song & Tao Yang & Haiqin Wang & Yanpeng Liang & Liangliang Huang & Honghu Zeng, 2023. "Endocrine Disruption of Propylparaben in the Male Mosquitofish ( Gambusia affinis ): Tissue Injuries and Abnormal Gene Expressions of Hypothalamic-Pituitary-Gonadal-Liver Axis," IJERPH, MDPI, vol. 20(4), pages 1-21, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:4:p:684-:d:139719. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.