IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i3p414-d133778.html
   My bibliography  Save this article

Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

Author

Listed:
  • Gaurav Sharma

    (Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
    Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
    School of Chemistry, Shoolini University, Solan 173212, India)

  • Mu. Naushad

    (Department of Chemistry, College of Science, Bld.#5, King Saud University, Riyadh 11451, Saudi Arabia)

  • Bharti Thakur

    (School of Chemistry, Shoolini University, Solan 173212, India)

  • Amit Kumar

    (Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
    Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
    School of Chemistry, Shoolini University, Solan 173212, India)

  • Poonam Negi

    (School of Pharmaceutical Sciences, Shoolini University, Solan 173212, India)

  • Reena Saini

    (School of Applied Science and Biotechnology, Shoolini University, Solan 173212, India)

  • Anterpreet Chahal

    (School of Applied Science and Biotechnology, Shoolini University, Solan 173212, India)

  • Ashok Kumar

    (Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, India)

  • Florian J. Stadler

    (Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China)

  • U.M.H. Aqil

    (School of Public Health, 3rd Floor, SRM Medical College and Research, Centre, Kattankulathur 603211, India)

Abstract

Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.

Suggested Citation

  • Gaurav Sharma & Mu. Naushad & Bharti Thakur & Amit Kumar & Poonam Negi & Reena Saini & Anterpreet Chahal & Ashok Kumar & Florian J. Stadler & U.M.H. Aqil, 2018. "Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron," IJERPH, MDPI, vol. 15(3), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:3:p:414-:d:133778
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/3/414/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/3/414/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:3:p:414-:d:133778. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.