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Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer

Author

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  • Po-Hung Lin

    (Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan
    Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Po-Hung Lin and Jui-Ming Liu contributed equally to this work.)

  • Jui-Ming Liu

    (Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
    Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Po-Hung Lin and Jui-Ming Liu contributed equally to this work.)

  • Ren-Jun Hsu

    (Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Biobank Management Center of Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
    Department of Pathology and Graduate Institute of Pathology and Parasitology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan)

  • Heng-Chang Chuang

    (Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan)

  • Su-Wei Chang

    (Clinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, 333 Taoyuan, Taiwan)

  • See-Tong Pang

    (Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan)

  • Ying-Hsu Chang

    (Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan)

  • Cheng-Keng Chuang

    (Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan)

  • Shun-Ku Lin

    (Department of Traditional Chinese medicine, Taipei City Hospital, Ren-Ai Branch, Taipei 106, Taiwan
    Institute of Public Health, National Yangming University, Taipei 112, Taiwan)

Abstract

The prevalence of depression in patients with cancer is high, especially for patients with advanced cancer. In this study, we evaluated the prevalence of depression in prostate cancer patients in Taiwan and the association between depression and mortality in prostate cancer. This study included 1101 newly diagnosed patients with prostate cancer. We tracked the medical information of these patients from diagnosis until the end of 2012. Patients were divided into two groups according to presence or absence of depression diagnosis, and were further divided into three stages by initial treatments: localized or locally advanced, metastatic, and castration-resistant prostate cancer. Of 1101 participants, 267 (24.3%) had depression. By the end of the follow-up period (M = 8.30 ± 3.12 years), 77 (28.8%) patients in the depression group and 194 (23.3%) in the non-depressed group died. Depression was associated with higher mortality risk, (aHR 1.37; 95% CI [ 1.04–1.80]; p value 0.01). Patients in the metastatic prostate cancer group with depression had a significantly higher mortality risk compared to the non-depressed group, (aHR, 1.49; 95% CI [1.05–2.11]; p value 0.02). The impact of depression on mortality risk was not significant in either the localized or locally advanced or the castration-resistant prostate cancer groups. Our study showed that depression is related to an increased mortality risk for patients with prostate cancer, especially for metastatic prostate cancer. These results indicate that urologists should pay attention to the mood and psychiatric disorders of patients with prostate cancer.

Suggested Citation

  • Po-Hung Lin & Jui-Ming Liu & Ren-Jun Hsu & Heng-Chang Chuang & Su-Wei Chang & See-Tong Pang & Ying-Hsu Chang & Cheng-Keng Chuang & Shun-Ku Lin, 2018. "Depression Negatively Impacts Survival of Patients with Metastatic Prostate Cancer," IJERPH, MDPI, vol. 15(10), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:10:p:2148-:d:172900
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    Cited by:

    1. Cristiano Scandurra & Benedetta Muzii & Roberto La Rocca & Francesco Di Bello & Mario Bottone & Gianluigi Califano & Nicola Longo & Nelson Mauro Maldonato & Francesco Mangiapia, 2022. "Social Support Mediates the Relationship between Body Image Distress and Depressive Symptoms in Prostate Cancer Patients," IJERPH, MDPI, vol. 19(8), pages 1-10, April.

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