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Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy

Author

Listed:
  • Francesco Miconi

    (Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy)

  • Emanuela Savarese

    (Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy)

  • Giovanni Miconi

    (Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy)

  • Gabriele Cabiati

    (Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy)

  • Valentina Rapaccini

    (Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy)

  • Nicola Principi

    (Pediatric Highly Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy)

  • Susanna Esposito

    (Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy)

Abstract

Background: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison’s disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. Case presentation: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced. Conclusion: This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD.

Suggested Citation

  • Francesco Miconi & Emanuela Savarese & Giovanni Miconi & Gabriele Cabiati & Valentina Rapaccini & Nicola Principi & Susanna Esposito, 2017. "Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy," IJERPH, MDPI, vol. 14(8), pages 1-6, July.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:8:p:855-:d:106307
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