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In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention

Author

Listed:
  • Ahmad M. Al-Thobity

    (Department of Substitutive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia)

  • Khalifa S. Al-Khalifa

    (Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia)

  • Mohammed M. Gad

    (Department of Substitutive Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia)

  • Mohammed Al-Hariri

    (Department of Physiology, College of Medicine, University of Dammam, Dammam 32214, Saudi Arabia)

  • Aiman A. Ali

    (Department of Biomedical Dental Sciences, College of Dentistry, University of Dammam, Dammam 32214, Saudi Arabia
    Current address: Oral Pathology and Oral Medicine, Faculty of Dentistry, University of Toronto, 124 Edward St. Room 314, Toronto, ON M5G 1G6, Canada.)

  • Talal Alnassar

    (Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh 11692, Saudi Arabia
    Department of Oral Rehabilitation, Dental College of Georgia, Augusta University, Augusta 30912, GA, USA)

Abstract

Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans . Eighty acrylic resin specimens were fabricated and divided into eight groups ( n = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on Candida albicans : the slide count and the serial dilution test. A multivariate analysis of variance (MANOVA) and the post-hoc Tukey’s Honestly Significant Difference (HSD) test were performed to compare the difference of means between the observations taken at various intervals with baseline. The p value was statistically significant at ≤0.05. According to the slide count and the serial dilution test, the mean number of adhered Candida albicans in the control group was 5436.9 ± 266 and 4691.4 ± 176.8; however, this number dramatically decreased to 0 ± 0 and 32.4 ± 1.7 in group 8 (concentration 5%). These results suggest that the incorporation of thymoquinone into the acrylic resin denture base material might be effective in preventing Candida albicans adhesion.

Suggested Citation

  • Ahmad M. Al-Thobity & Khalifa S. Al-Khalifa & Mohammed M. Gad & Mohammed Al-Hariri & Aiman A. Ali & Talal Alnassar, 2017. "In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention," IJERPH, MDPI, vol. 14(7), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:7:p:743-:d:104035
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    References listed on IDEAS

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    1. Amal Nawasrah & Amani AlNimr & Aiman A. Ali, 2016. "Antifungal Effect of Henna against Candida albicans Adhered to Acrylic Resin as a Possible Method for Prevention of Denture Stomatitis," IJERPH, MDPI, vol. 13(5), pages 1-8, May.
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