IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i6p657-d101965.html
   My bibliography  Save this article

Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans

Author

Listed:
  • Stephanie Ly

    (Division of Plastic & Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Department of Community Health Sciences and California Center for Population Research (CCPR), UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA)

  • Madeleine L. Burg

    (Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA)

  • Ugonna Ihenacho

    (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA)

  • Frederick Brindopke

    (Division of Plastic & Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA)

  • Allyn Auslander

    (Division of Plastic & Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA)

  • Kathleen S. Magee

    (Operation Smile Inc., Virginia Beach, VA 23453 USA)

  • Pedro A. Sanchez-Lara

    (Departments of Pediatrics and Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA)

  • Thi-Hai-Duc Nguyen

    (Operation Smile Vietnam, Hanoi 100803, Vietnam)

  • Viet Nguyen

    (Operation Smile Vietnam, Hanoi 100803, Vietnam)

  • Maria Irene Tangco

    (Operation Smile Philippines, Makati City 1209, Philippines
    Department of Surgery, Faculty of Medicine and Surgery, University of Santo Tomas, Manila 1008, Philippines)

  • Angela Rose Hernandez

    (Operation Smile Philippines, Makati City 1209, Philippines
    Department of Surgery, Faculty of Medicine and Surgery, University of Santo Tomas, Manila 1008, Philippines)

  • Melissa Giron

    (Operación Sonrisa Honduras, Tegucigalpa 11101, Honduras)

  • Fouzia J. Mahmoudi

    (Operation Smile Morocco, Casablanca 20 000, Morocco)

  • Yves A. DeClerck

    (Departments of Pediatrics and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California and Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA)

  • William P. Magee III

    (Division of Plastic & Maxillofacial Surgery, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA)

  • Jane C. Figueiredo

    (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center 8700 Beverly Blvd, Room AC1072, Los Angeles, CA 90048, USA)

Abstract

While several studies have investigated maternal exposures as risk factors for oral clefts, few have examined paternal factors. We conducted an international multi-centered case–control study to better understand paternal risk exposures for oral clefts (cases = 392 and controls = 234). Participants were recruited from local hospitals and oral cleft repair surgical missions in Vietnam, the Philippines, Honduras, and Morocco. Questionnaires were administered to fathers and mothers separately to elicit risk factor and family history data. Associations between paternal exposures and risk of clefts were assessed using logistic regression adjusting for potential confounders. A father’s personal/family history of clefts was associated with significantly increased risk (adjusted OR: 4.77; 95% CI: 2.41–9.45). No other significant associations were identified for other suspected risk factors, including education (none/primary school v. university adjusted OR: 1.29; 95% CI: 0.74–2.24), advanced paternal age (5-year adjusted OR: 0.98; 95% CI: 0.84–1.16), or pre-pregnancy tobacco use (adjusted OR: 0.96; 95% CI: 0.67–1.37). Although sample size was limited, significantly decreased risks were observed for fathers with selected occupations. Further research is needed to investigate paternal environmental exposures as cleft risk factors.

Suggested Citation

  • Stephanie Ly & Madeleine L. Burg & Ugonna Ihenacho & Frederick Brindopke & Allyn Auslander & Kathleen S. Magee & Pedro A. Sanchez-Lara & Thi-Hai-Duc Nguyen & Viet Nguyen & Maria Irene Tangco & Angela , 2017. "Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans," IJERPH, MDPI, vol. 14(6), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:657-:d:101965
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/6/657/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/6/657/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:657-:d:101965. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.