IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i6p653-d101877.html
   My bibliography  Save this article

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Author

Listed:
  • Huixian Hou

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work)

  • Rulin Ma

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China
    These authors contributed equally to this work)

  • Heng Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jia He

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yunhua Hu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Lati Mu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yizhong Yan

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jiaolong Ma

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Shugang Li

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jingyu Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Yusong Ding

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Mei Zhang

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Qiang Niu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Jiaming Liu

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

  • Shuxia Guo

    (Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China)

Abstract

Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS. Methods: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method. Results: (1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all p < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all p < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all p < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D’ = 1.000, r 2 = 0.931), rs711752 and rs708272 (D’ = 1.000, r 2 = 0.996)). (5) The A-G-G-G-C ( p = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427–0.906) and A-T-A-A-T ( p < 0.001, OR = 0.519, 95% CI = 0.386–0.697) haplotypes were more frequent in the control group than in the case group. Conclusions : The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.

Suggested Citation

  • Huixian Hou & Rulin Ma & Heng Guo & Jia He & Yunhua Hu & Lati Mu & Yizhong Yan & Jiaolong Ma & Shugang Li & Jingyu Zhang & Yusong Ding & Mei Zhang & Qiang Niu & Jiaming Liu & Shuxia Guo, 2017. "Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China," IJERPH, MDPI, vol. 14(6), pages 1-14, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:653-:d:101877
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/6/653/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/6/653/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Shuxia Guo & Yunhua Hu & Yusong Ding & Jiaming Liu & Mei Zhang & Rulin Ma & Heng Guo & Kui Wang & Jia He & Yizhong Yan & Dongsheng Rui & Feng Sun & Lati Mu & Qiang Niu & Jingyu Zhang & Shugang Li, 2015. "Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China," IJERPH, MDPI, vol. 12(12), pages 1-14, December.
    2. Xiang-Hui Zhang & Mei Zhang & Jia He & Yi-Zhong Yan & Jiao-Long Ma & Kui Wang & Ru-Lin Ma & Heng Guo & La-Ti Mu & Yu-Song Ding & Jing-Yu Zhang & Jia-Ming Liu & Shu-Gang Li & Qiang Niu & Dong-Sheng Rui, 2016. "Comparison of Anthropometric and Atherogenic Indices as Screening Tools of Metabolic Syndrome in the Kazakh Adult Population in Xinjiang," IJERPH, MDPI, vol. 13(4), pages 1-12, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jia He & Rulin Ma & Jiaming Liu & Mei Zhang & Yusong Ding & Heng Guo & Lati Mu & Jingyu Zhang & Bin Wei & Yizhong Yan & Jiaolong Ma & Hongrui Pang & Shugang Li & Shuxia Guo, 2017. "The Optimal Ethnic-Specific Waist-Circumference Cut-Off Points of Metabolic Syndrome among Low-Income Rural Uyghur Adults in Far Western China and Implications in Preventive Public Health," IJERPH, MDPI, vol. 14(2), pages 1-12, February.
    2. Ming-hong Yao & Heng Guo & Jia He & Yi-zhong Yan & Ru-lin Ma & Yu-song Ding & Jing-yu Zhang & Jia-ming Liu & Mei Zhang & Shu-gang Li & Shang-zhi Xu & Qiang Niu & Jiao-long Ma & Shu-xia Guo, 2016. "Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China," IJERPH, MDPI, vol. 13(2), pages 1-14, January.
    3. Dongxue Dai & Ye Chang & Yintao Chen & Shuang Chen & Shasha Yu & Xiaofan Guo & Yingxian Sun, 2016. "Visceral Adiposity Index and Lipid Accumulation Product Index: Two Alternate Body Indices to Identify Chronic Kidney Disease among the Rural Population in Northeast China," IJERPH, MDPI, vol. 13(12), pages 1-11, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:653-:d:101877. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.