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The Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)

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  • Dong Yang

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

  • Zhigang Qiu

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

  • Zhiqiang Shen

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

  • Hong Zhao

    (Animals, Plants and Food Testing Center of Tianjin Exit-Entry Inspection & Quarantine Bureau, Tianjin 300461, China)

  • Min Jin

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

  • Huaying Li

    (Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazards, Logistics University of Chinese People’s Armed Police Forces, No. 1, Hui-Zhi Ring Road, Tianjin 300309, China)

  • Weili Liu

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

  • Jun-Wen Li

    (Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine; Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No.1, Dali Road, Tianjin 300050, China)

Abstract

Antibiotic failure is occurring worldwide. In a routine surveillance study on antibioticresistance genes (ARGs) in natural water bodies, we noted the detection of colistin-resistance gene mcr-1, previously identified in Escherichia coli and Klebsiella pneumoniae isolates from human beings and animals in several countries. The mcr-1 gene might be present in water environments, because aquatic ecosystems are recognized as reservoirs for antibiotic resistant bacteria (ARB) and ARGs. In this study, a qPCR assay was developed to monitor and quantify the mcr-1 gene in the Haihe River, China. The results showed that all 18 samples collected from different locations over 6 months along the Haihe River were positive for the mcr-1 gene, and the highest level of mcr-1 reached 3.81 × 105 gene copies (GC) per liter of water. This is the first study to quantify mcr-1 in a natural water system by qPCR. Our findings highlight the potential for this antibiotic resistance determinant to spread extensively, suggesting a significant health and ecological impact.

Suggested Citation

  • Dong Yang & Zhigang Qiu & Zhiqiang Shen & Hong Zhao & Min Jin & Huaying Li & Weili Liu & Jun-Wen Li, 2017. "The Occurrence of the Colistin Resistance Gene mcr-1 in the Haihe River (China)," IJERPH, MDPI, vol. 14(6), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:576-:d:99968
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    References listed on IDEAS

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    1. Toqeer Ahmed & Miklas Scholz & Furat Al-Faraj & Wajeeha Niaz, 2016. "Water-Related Impacts of Climate Change on Agriculture and Subsequently on Public Health: A Review for Generalists with Particular Reference to Pakistan," IJERPH, MDPI, vol. 13(11), pages 1-16, October.
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    Cited by:

    1. Carlos Bastidas-Caldes & Juan Ochoa & Laura Guerrero-Latorre & Carlos Moyota-Tello & Wilson Tapia & Joaquín María Rey-Pérez & Maria Isabel Baroja, 2022. "Removal of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli , ST98, in Water for Human Consumption by Black Ceramic Water Filters in Low-Income Ecuadorian Highlands," IJERPH, MDPI, vol. 19(8), pages 1-12, April.

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