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FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes

Author

Listed:
  • Meng-Chuan Huang

    (Department of Public Health and Environmental Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Department of Nutrition and Dietetics, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan)

  • Wen-Tsan Chang

    (Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan)

  • Hsin-Yu Chang

    (Department of Public Health and Environmental Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Hsin-Fang Chung

    (School of Public Health, University of Queensland, Brisbane, Queensland 4006, Australia)

  • Fang-Pei Chen

    (Department of Nutrition and Health Sciences, College of Health Sciences, Chang-Jung Christian University, Tainan 71101, Taiwan)

  • Ya-Fang Huang

    (Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan)

  • Chih-Cheng Hsu

    (Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
    Department of Health Services Administration, China Medical University, Taichung 40402, Taiwan)

  • Shang-Jyh Hwang

    (Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University and University Hospital, Kaohsiung 80708, Taiwan)

Abstract

Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. Fatty acid desaturase ( FADS ) single nucleotide polymorphisms (SNPs) modulate circulating PUFA concentrations. This study examined influence of FADS1 and FADS2 genetic variants on desaturase activities and blood lipid concentrations in type 2 diabetes patients, and further assessed their interrelationships. Selected SNPs ( FADS1 : rs174547, rs174548, rs174550; FADS2 : rs174575, rs174576, rs174583, rs498793 and rs2727270) were genotyped in 820 type 2 diabetes patients and compared with those reported in the HapMap. Patient subgroups ( n = 176) without taking lipid-lowering medicine were studied to assess influence of tag SNPs including rs174547, rs174575, rs498793 and rs2727270 on delta-5 desaturase (D5D: 20:4 (n-6)/20:3 (n-6)) and delta-6 desaturase (D6D:18:3 (n-6)/18:2 (n-6)) activities, and blood lipids. FADS1 rs174547 TT/TC/CC and FADS2 rs2727270 CC/CT/TT were significantly ( p for trend < 0.05) associated with reduced HDL-C, D5D and D6D activities. Upon adjustment for confounders, D5D ( p = 0.006) correlated significantly and D6D marginally ( p = 0.07) correlated with increased HDL-C levels, whereas rs174547 and rs2727270 polymorphisms were not associated. D6D andD5D activities may play a role in modulating HDL-C levels in type 2 diabetes. Future studies with larger sample sizes are needed to investigate how FADS genetic variations interact with desaturase activities or PUFAs in the metabolism of lipoproteins in diabetic patients.

Suggested Citation

  • Meng-Chuan Huang & Wen-Tsan Chang & Hsin-Yu Chang & Hsin-Fang Chung & Fang-Pei Chen & Ya-Fang Huang & Chih-Cheng Hsu & Shang-Jyh Hwang, 2017. "FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes," IJERPH, MDPI, vol. 14(6), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:572-:d:99915
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