IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i5p514-d98170.html
   My bibliography  Save this article

Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease

Author

Listed:
  • Yaqin Wang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Xintong Wang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Zhenyu Li

    (Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China)

  • Lulu Chen

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Luping Zhou

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Chaopeng Li

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Dong-sheng Ouyang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

Abstract

The coronary artery disease (CAD) is one of the most severe cardiovascular diseases. MicroRNA-146a (miR-146a) influences the pathology of cardiovascular diseases. Two single nucleotide polymorphisms (SNPs) of miR-146a (rs2431697 and rs2910164) have been reported to alter the function or expression of microRNA. The purpose of this study is to evaluate the association between miR-146a gene polymorphism and the risk of CAD in the Chinese population. A total of 353 CAD patients and 368 controls were recruited, and SNPs were analyzed by the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Sequenom MassARRAY system. The gene frequencies of rs2431697 and rs2910164 were significantly different between the two groups. The mutant type (T allele) of rs2431697 and wild type (C allele) of rs2910164 were more frequent in CAD patients. T allele carriers in rs2431697 had an increased CAD risk, while G allele of rs2910164 decreased the risk of CAD significantly. In conclusion, we found that the T allele of rs2431697 was a risk factor of CAD in the Chinese population. Meanwhile, we demonstrated that the G allele of rs2910164 decreased the susceptibility of CAD.

Suggested Citation

  • Yaqin Wang & Xintong Wang & Zhenyu Li & Lulu Chen & Luping Zhou & Chaopeng Li & Dong-sheng Ouyang, 2017. "Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease," IJERPH, MDPI, vol. 14(5), pages 1-7, May.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:5:p:514-:d:98170
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/5/514/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/5/514/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:5:p:514-:d:98170. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.