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Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study

Author

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  • Xuemin Zhao

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Shiqiao Peng

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Yang Xiang

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Yali Yang

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Jing Li

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Zhongyan Shan

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Weiping Teng

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

Abstract

Only a few epidemiological studies have focused on the correlation between prenatal exposure to polybrominated diphenyl ethers (PBDEs) and infant birth outcomes (IBO), and the results of these epidemiological studies are contradictory. The objective of this study was to assess the correlation between prenatal exposure to PBDEs (PEP) and IBO (i.e., birth weight) in an analysis of epidemiological studies and an experimental animals study. We searched databases of the medical literature (PubMed, Excerpta Medica Database, Cochrane Library, and China National Knowledge Infrastructure) for articles and pooled the results of the included epidemiological studies. In parallel, birth outcomes (i.e., birth weights of pups) were collected from female Sprague-Dawley (SD) rats exposed to decabromodiphenyl ether (DecaBDE) in the diet from five weeks of age to delivery. A significant negative relationship was found between human PBDE burden and birth weight in the analysis of seven epidemiological studies based on a random-effects model (β = −50.598; 95% confidence interval (CI) −95.914, −5.282; I 2 = 11.8%; p = 0.029). In the experimental animal study, a significant decrease in birth weight in the DecaBDE-treated group was also observed (5.26 ± 0.39 vs. 5.8 ± 0.58, p = 0.0132). The results of our study contribute to increasing evidence suggesting that PEP adversely impacts IBO, especially birth weight.

Suggested Citation

  • Xuemin Zhao & Shiqiao Peng & Yang Xiang & Yali Yang & Jing Li & Zhongyan Shan & Weiping Teng, 2017. "Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study," IJERPH, MDPI, vol. 14(3), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:268-:d:92394
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    References listed on IDEAS

    as
    1. Xuemin Zhao & Hailong Wang & Jing Li & Zhongyan Shan & Weiping Teng & Xiaochun Teng, 2015. "The Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Hormones in the General Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-17, May.
    2. Mi-Yeon Shin & Sunggyu Lee & Hai-Joong Kim & Jeong Jae Lee & Gyuyeon Choi & Sooran Choi & Sungjoo Kim & Su Young Kim & Jeongim Park & Hyo-Bang Moon & Kyungho Choi & Sungkyoon Kim, 2016. "Polybrominated Diphenyl Ethers in Maternal Serum, Breast Milk, Umbilical Cord Serum, and House Dust in a South Korean Birth Panel of Mother-Neonate Pairs," IJERPH, MDPI, vol. 13(8), pages 1-15, July.
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