IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i3p268-d92394.html
   My bibliography  Save this article

Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study

Author

Listed:
  • Xuemin Zhao

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Shiqiao Peng

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Yang Xiang

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Yali Yang

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Jing Li

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Zhongyan Shan

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

  • Weiping Teng

    (Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China)

Abstract

Only a few epidemiological studies have focused on the correlation between prenatal exposure to polybrominated diphenyl ethers (PBDEs) and infant birth outcomes (IBO), and the results of these epidemiological studies are contradictory. The objective of this study was to assess the correlation between prenatal exposure to PBDEs (PEP) and IBO (i.e., birth weight) in an analysis of epidemiological studies and an experimental animals study. We searched databases of the medical literature (PubMed, Excerpta Medica Database, Cochrane Library, and China National Knowledge Infrastructure) for articles and pooled the results of the included epidemiological studies. In parallel, birth outcomes (i.e., birth weights of pups) were collected from female Sprague-Dawley (SD) rats exposed to decabromodiphenyl ether (DecaBDE) in the diet from five weeks of age to delivery. A significant negative relationship was found between human PBDE burden and birth weight in the analysis of seven epidemiological studies based on a random-effects model (β = −50.598; 95% confidence interval (CI) −95.914, −5.282; I 2 = 11.8%; p = 0.029). In the experimental animal study, a significant decrease in birth weight in the DecaBDE-treated group was also observed (5.26 ± 0.39 vs. 5.8 ± 0.58, p = 0.0132). The results of our study contribute to increasing evidence suggesting that PEP adversely impacts IBO, especially birth weight.

Suggested Citation

  • Xuemin Zhao & Shiqiao Peng & Yang Xiang & Yali Yang & Jing Li & Zhongyan Shan & Weiping Teng, 2017. "Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study," IJERPH, MDPI, vol. 14(3), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:268-:d:92394
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/3/268/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/3/268/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Mi-Yeon Shin & Sunggyu Lee & Hai-Joong Kim & Jeong Jae Lee & Gyuyeon Choi & Sooran Choi & Sungjoo Kim & Su Young Kim & Jeongim Park & Hyo-Bang Moon & Kyungho Choi & Sungkyoon Kim, 2016. "Polybrominated Diphenyl Ethers in Maternal Serum, Breast Milk, Umbilical Cord Serum, and House Dust in a South Korean Birth Panel of Mother-Neonate Pairs," IJERPH, MDPI, vol. 13(8), pages 1-15, July.
    2. Xuemin Zhao & Hailong Wang & Jing Li & Zhongyan Shan & Weiping Teng & Xiaochun Teng, 2015. "The Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Hormones in the General Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-17, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vishal Singh & Javier Cortes-Ramirez & Leisa-Maree Toms & Thilakshika Sooriyagoda & Shamshad Karatela, 2022. "Effects of Polybrominated Diphenyl Ethers on Hormonal and Reproductive Health in E-Waste-Exposed Population: A Systematic Review," IJERPH, MDPI, vol. 19(13), pages 1-20, June.
    2. Alesia Ferguson & Rosalind Penney & Helena Solo-Gabriele, 2017. "A Review of the Field on Children’s Exposure to Environmental Contaminants: A Risk Assessment Approach," IJERPH, MDPI, vol. 14(3), pages 1-25, March.
    3. Francesca Gorini & Giorgio Iervasi & Alessio Coi & Letizia Pitto & Fabrizio Bianchi, 2018. "The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives," IJERPH, MDPI, vol. 15(9), pages 1-24, August.
    4. Ladan Rokni & Mehdi Rezaei & Mahdi Rafieizonooz & Elnaz Khankhajeh & Ali Akbar Mohammadi & Shahabaldin Rezania, 2023. "Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases," Sustainability, MDPI, vol. 15(14), pages 1-19, July.
    5. Alesia Ferguson & Helena Solo-Gabriele, 2016. "Children’s Exposure to Environmental Contaminants: An Editorial Reflection of Articles in the IJERPH Special Issue Entitled, “Children’s Exposure to Environmental Contaminants”," IJERPH, MDPI, vol. 13(11), pages 1-10, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:268-:d:92394. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.