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Comparative Epidemiology of Human Fatal Infections with Novel, High (H5N6 and H5N1) and Low (H7N9 and H9N2) Pathogenicity Avian Influenza A Viruses

Author

Listed:
  • Zu-Qun Wu

    (Department of Respiratory Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Zu-Qun Wu, Yi Zhang and Na Zhao equally contributed to this work.)

  • Yi Zhang

    (Department of Medicine, Jinxi Petrochemical Hospital, Huludao 125001, China
    Zu-Qun Wu, Yi Zhang and Na Zhao equally contributed to this work.)

  • Na Zhao

    (National Research Center for Wildlife Borne Diseases, Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Zu-Qun Wu, Yi Zhang and Na Zhao equally contributed to this work.)

  • Zhao Yu

    (Department of Infectious Diseases and Key Lab of Vaccine against Hemorrhagic Fever with Renal Syndrome, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China)

  • Hao Pan

    (Department of Infectious Diseases, Shanghai Municipal Centre for Disease Control and Prevention, Shanghai 200336, China)

  • Ta-Chien Chan

    (Center for Geographic Information Science, Research Centre for Humanities and Social Science, Academia Sinica, Taipei 115, Taiwan)

  • Zhi-Ruo Zhang

    (School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China)

  • She-Lan Liu

    (Department of Infectious Diseases and Key Lab of Vaccine against Hemorrhagic Fever with Renal Syndrome, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China)

Abstract

This study aimed to assess the mortality risks for human infection with high (HPAI) and low (LPAI) pathogenicity avian influenza viruses. The HPAI case fatality rate (CFR) was far higher than the LPAI CFR [66.0% (293/444) vs. 68.75% (11/16) vs. 40.4% (265/656) vs. 0.0% (0/18) in the cases with H5N1, H5N6, H7N9, and H9N2 viruses, respectively; p < 0.001]. Similarly, the CFR of the index cases was greater than the secondary cases with H5N1 [100% (43/43) vs. 43.3% (42/97), p < 0.001]. Old age [22.5 vs. 17 years for H5N1, p = 0.018; 61 vs. 49 years for H7H9, p < 0.001], concurrent diseases [18.8% (15/80) vs. 8.33% (9/108) for H5N1, p = 0.046; 58.6% (156/266) vs. 34.8% (135/388) for H7H9, p < 0.001], delayed confirmation [13 vs. 6 days for H5N1, p < 0.001; 10 vs. 8 days for H7N9, p = 0.011] in the fatalities and survivors, were risk factors for deaths. With regard to the H5N1 clusters, exposure to poultry [67.4% (29/43) vs. 45.2% (19/42), p = 0.039] was the higher risk for the primary than the secondary deaths. In conclusion, old age, comorbidities, delayed confirmation, along with poultry exposure are the major risks contributing to fatal outcomes in human HPAI and LPAI infections.

Suggested Citation

  • Zu-Qun Wu & Yi Zhang & Na Zhao & Zhao Yu & Hao Pan & Ta-Chien Chan & Zhi-Ruo Zhang & She-Lan Liu, 2017. "Comparative Epidemiology of Human Fatal Infections with Novel, High (H5N6 and H5N1) and Low (H7N9 and H9N2) Pathogenicity Avian Influenza A Viruses," IJERPH, MDPI, vol. 14(3), pages 1-20, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:263-:d:92187
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    References listed on IDEAS

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    1. Yi Zhang & Zhixiong Shen & Chunna Ma & Chengsheng Jiang & Cindy Feng & Nivedita Shankar & Peng Yang & Wenjie Sun & Quanyi Wang, 2015. "Cluster of Human Infections with Avian Influenza A (H7N9) Cases: A Temporal and Spatial Analysis," IJERPH, MDPI, vol. 12(1), pages 1-13, January.
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