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Toxicity Research of PM 2.5 Compositions In Vitro

Author

Listed:
  • Yi-Yang Jia

    (Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China)

  • Qi Wang

    (Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China)

  • Te Liu

    (Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China)

Abstract

According to the published literature, we surmise that particulate matter (PM) concentration, individually, may be less important than components in explaining health effects. PM 2.5 (aerodynamic diameter <2.5 μm) had similar cytotoxicity (e.g., cell viability reduction, oxidative damage, inflammatory effects and genetic toxicity) on different types of cells. The studies of cells are readily available for detailed mechanistic investigations, which is more appropriate for learning and comparing the mechanism caused by single or mixed ingredients coating a carbon core. No review exists that holistically examines the evidence from all components-based in vitro studies. We reviewed published studies that focus on the cytotoxicity of normal PM 2.5 . Those studies suggested that the toxicity of mixed compositions differs greatly from the single ingredients in mixed components and the target cells. The cytotoxic responses caused by PM 2.5 components have not shown a consistent association with clear, specific health effects. The results may be beneficial for providing new targets for drugs for the treatment of PM 2.5 -related diseases.

Suggested Citation

  • Yi-Yang Jia & Qi Wang & Te Liu, 2017. "Toxicity Research of PM 2.5 Compositions In Vitro," IJERPH, MDPI, vol. 14(3), pages 1-17, February.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:232-:d:91550
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    Cited by:

    1. Justyna Kujawska & Monika Kulisz & Piotr Oleszczuk & Wojciech Cel, 2022. "Machine Learning Methods to Forecast the Concentration of PM10 in Lublin, Poland," Energies, MDPI, vol. 15(17), pages 1-23, September.

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