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Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis

Author

Listed:
  • Shi-Qi Huang

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China
    These authors contributed equally to this work.)

  • Na Zhang

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China
    Department of Preventive Medicine, Zunyi Medical College, Zhuhai Campus, Zhuhai 519041, Guangdong, China
    These authors contributed equally to this work.)

  • Zi-Xing Zhou

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Chui-Can Huang

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Cheng-Li Zeng

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Di Xiao

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Cong-Cong Guo

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Ya-Jing Han

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Xiao-Hong Ye

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Xing-Guang Ye

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Mei-Ling Ou

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Bao-Huan Zhang

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Yang Liu

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China)

  • Eddy Y. Zeng

    (School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China)

  • Guang Yang

    (School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China
    Department of Parasitology, School of Basic Medical Sciences, Jinan University, Guangzhou 510632, Guangdong, China)

  • Chun-Xia Jing

    (Department of Epidemiology, School of Basic Medical Sciences, Jinan University, No.601 Huangpu Road West, Guangzhou 510632, Guangdong, China
    School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China)

Abstract

Background: Lipoma preferred partner ( LPP ) and T-cell activation Rho GTPase activating protein ( TAGAP ) polymorphisms might influence the susceptibility to celiac disease. Therefore, we performed a meta-analysis by identifying relevant studies to estimate the risks of these polymorphisms on celiac disease. Methods: The PubMed, Web of Science and Embase databases were searched (up to October 2016) for LPP rs1464510 and TAGAP rs1738074 polymorphisms. Results: This meta-analysis included the same 7 studies for LPP rs1464510 and TAGAP rs1738074. The minor risk A allele at both rs1464510 and rs1738074 carried risks (odds ratios) of 1.26 (95% CI: 1.22–1.30) and 1.17 (95% CI: 1.14–1.21), respectively, which contributed to increased risks in all celiac disease patients by 10.72% and 6.59%, respectively. The estimated lambdas were 0.512 and 0.496, respectively, suggesting that a co-dominant model would be suitable for both gene effects. Conclusions: This meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in European and American. Prospective studies and more genome-wide association studies (GWAS) are needed to confirm these findings, and some corresponding molecular biology experiments should be carried out to clarify the pathogenic mechanisms of celiac disease.

Suggested Citation

  • Shi-Qi Huang & Na Zhang & Zi-Xing Zhou & Chui-Can Huang & Cheng-Li Zeng & Di Xiao & Cong-Cong Guo & Ya-Jing Han & Xiao-Hong Ye & Xing-Guang Ye & Mei-Ling Ou & Bao-Huan Zhang & Yang Liu & Eddy Y. Zeng , 2017. "Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis," IJERPH, MDPI, vol. 14(2), pages 1-17, February.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:2:p:171-:d:89882
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