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Critical Windows of Prenatal Exposure to Cadmium and Size at Birth

Author

Listed:
  • Lu Cheng

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Bin Zhang

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    Women and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, China)

  • Tongzhang Zheng

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Jie Hu

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Aifen Zhou

    (Women and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, China)

  • Bryan A. Bassig

    (Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA)

  • Wei Xia

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • David A. Savitz

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Stephen Buka

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Chao Xiong

    (Women and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, China)

  • Joseph M. Braun

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Yaqi Zhang

    (Women and Children Medical and Healthcare Center of Wuhan, Wuhan 430000, Hubei, China)

  • Yanqiu Zhou

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Xinyun Pan

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Chuansha Wu

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Youjie Wang

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Zhengmin Qian

    (Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO 63103, USA)

  • Aimin Yang

    (College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000, Gansu, China)

  • Megan E. Romano

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Kunchong Shi

    (Department of Epidemiology, Brown University, Providence, RI 02912, USA)

  • Shunqing Xu

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China)

  • Yuanyuan Li

    (Key Laboratory of Environment and Health (HUST), Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China
    Department of Epidemiology, Brown University, Providence, RI 02912, USA)

Abstract

Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. We measured Cd concentrations in urine samples at or near 13, 24, and 35 gestational weeks from 282 women in Wuhan, China. We used generalized estimating equation models to assess the associations between maternal creatinine adjusted urinary Cd concentrations at each trimester and birth size. A significant inverse association was observed between higher maternal Cd levels measured during the 1st trimester and birth size in girls. For each log unit increase in Cd (µg/g creatinine) levels from the 1st trimester, there was a decrease in birth weight by 116.99 g (95% confidence interval (CI): −208.87, −25.11 g). The Cd levels from the 1st and 2nd trimesters were also borderline significantly associated with ponderal index in girls. Joint estimation of trimester-specific effects suggested that associations with Cd levels for ponderal index ( p int = 0.02) were significantly different across trimesters, and differences for effects across trimesters for birth weight were marginally significant ( p int = 0.08) in girls. No significant associations were observed between Cd levels from any trimester and birth size in boys. Maternal Cd exposure during earlier periods of pregnancy may have a larger impact on delayed fetal growth.

Suggested Citation

  • Lu Cheng & Bin Zhang & Tongzhang Zheng & Jie Hu & Aifen Zhou & Bryan A. Bassig & Wei Xia & David A. Savitz & Stephen Buka & Chao Xiong & Joseph M. Braun & Yaqi Zhang & Yanqiu Zhou & Xinyun Pan & Chuan, 2017. "Critical Windows of Prenatal Exposure to Cadmium and Size at Birth," IJERPH, MDPI, vol. 14(1), pages 1-11, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:58-:d:87258
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    Cited by:

    1. Xin-Chen Liu & Esben Strodl & Li-Hua Huang & Qing Lu & Yang Liang & Wei-Qing Chen, 2022. "First Trimester of Pregnancy as the Sensitive Period for the Association between Prenatal Mosquito Coil Smoke Exposure and Preterm Birth," IJERPH, MDPI, vol. 19(18), pages 1-12, September.

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