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Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Author

Listed:
  • Aya Hisada

    (Department of Public Health, Faculty of Life Sciences, Kumamoto University, Honjyo 1-1-1, Chuo-ku, Kumamoto 860-8556, Japan)

  • Jun Yoshinaga

    (Department of Environmental Systems, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8563, Japan
    Faculty of Life Sciences, Toyo University, Izumino 1-1-1, Itakura, Oura, Gunma 374-0193, Japan)

  • Jie Zhang

    (Department of Environmental Systems, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8563, Japan)

  • Takahiko Katoh

    (Department of Public Health, Faculty of Life Sciences, Kumamoto University, Honjyo 1-1-1, Chuo-ku, Kumamoto 860-8556, Japan)

  • Hiroaki Shiraishi

    (National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, Ibaraki 305-8056, Japan)

  • Kazuhisa Shimodaira

    (Department of Obstetrics and Gynecology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Takashi Okai

    (Department of Obstetrics and Gynecology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Nagako Ariki

    (Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Yoko Komine

    (Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Miyako Shirakawa

    (Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Yumiko Noda

    (Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

  • Nobumasa Kato

    (Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan)

Abstract

The possible association between maternal exposure to pyrethroid insecticides (PYRs) during pregnancy and infant development was explored. Levels of exposure to PYRs was assessed by metabolite (3-phenoybenzoic acid, 3-PBA) concentration in maternal spot urine sampled in the first trimester of index pregnancy, and infant development was assessed at 18 months of age using the Kinder Infants Development Scale (KIDS), which is based on a questionnaire to the caretaker. The relationship between KIDS score and maternal urinary 3-PBA levels was examined by a stepwise multiple regression analysis using biological attributes of the mother and infant, breast feeding, and nursing environment as covariates. The analysis extracted 3-PBA and the nursing environment as significant to explain the KIDS score at 18 months of age with positive partial regression coefficients. Inclusion of fish consumption frequency of the mother during pregnancy as an independent variable resulted in the selection of fish consumption as significant, while the two variables were marginally insignificant but still with a positive coefficient with the KIDS score. The result suggested a positive effect of maternal PYR exposure on infant development, the reason for which is not clear, but an unknown confounding factor is suspected.

Suggested Citation

  • Aya Hisada & Jun Yoshinaga & Jie Zhang & Takahiko Katoh & Hiroaki Shiraishi & Kazuhisa Shimodaira & Takashi Okai & Nagako Ariki & Yoko Komine & Miyako Shirakawa & Yumiko Noda & Nobumasa Kato, 2017. "Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age," IJERPH, MDPI, vol. 14(1), pages 1-9, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:52-:d:87189
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    Cited by:

    1. Keisuke Nojiri & Shunjiro Kobayashi & Satoshi Higurashi & Tomoki Takahashi & Yuta Tsujimori & Hiroshi M. Ueno & Shiomi Watanabe-Matsuhashi & Yasuhiro Toba & Junichi Yamamura & Taku Nakano & Kyoko Nomu, 2020. "Maternal Health and Nutrition Status, Human Milk Composition, and Growth and Development of Infants and Children: A Prospective Japanese Human Milk Study Protocol," IJERPH, MDPI, vol. 17(6), pages 1-10, March.

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