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Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water

Author

Listed:
  • Alexander Hladicz

    (Center for Molecular Biology, University of Vienna, 1030 Vienna, Austria
    Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Neue Stiftingtalstrasse 2, 8010 Graz, Austria)

  • Clemens Kittinger

    (Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Neue Stiftingtalstrasse 2, 8010 Graz, Austria)

  • Gernot Zarfel

    (Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Neue Stiftingtalstrasse 2, 8010 Graz, Austria)

Abstract

: Antibiotic-resistant bacteria are spreading worldwide in medical settings but also in the environment. These resistant bacteria illustrate a major health problem in our times, and last-line antibiotics such as tigecycline represent an ultimate therapy option. Reports on tigecycline non-susceptible Enterobacteriaceae are presented with regard to medical settings but are rare with that for the environment. The aim of this study was to characterize two tigecycline non-susceptible Klebsiella pneumoniae isolates from the river Mur, and to question the resistance mechanism. The screening for chromosomal mutations revealed a deletion and a silent point mutation in one isolate and a point mutation in the other isolate all within the ramR allele. RamR acts as repressor and prevents overexpression of ramA . These mutations are likely to cause a resistant phenotype due to the overexpression of AcrAB-TolC. MLST revealed that the isolates belonged to two unrelated MLST types (ST2392 and ST2394). Both isolates only revealed resistance to tigecycline and tetracycline. This is one of the rare reports of tigecycline-resistant Klebsiella pneumoniae from surface water. The presence of two genetically different isolates suggests that the river water may bear substances that favor mutations that can lead to this efflux pump-driven resistance.

Suggested Citation

  • Alexander Hladicz & Clemens Kittinger & Gernot Zarfel, 2017. "Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water," IJERPH, MDPI, vol. 14(10), pages 1-8, October.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:10:p:1169-:d:114002
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    Citations

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    Cited by:

    1. Wenxia Wang & Xiaohong Gu & Lijun Zhou & Huihui Chen & Qingfei Zeng & Zhigang Mao, 2018. "Antibiotics in Crab Ponds of Lake Guchenghu Basin, China: Occurrence, Temporal Variations, and Ecological Risks," IJERPH, MDPI, vol. 15(3), pages 1-12, March.
    2. Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2019. "Antimicrobials and Antimicrobial Resistance in the Environment and Its Remediation: A Global One Health Perspective," IJERPH, MDPI, vol. 16(23), pages 1-7, November.
    3. Junjun Ma & Bing Li & Lincheng Zhou & Yin Zhu & Ji Li & Yong Qiu, 2018. "Simple Urea Immersion Enhanced Removal of Tetracycline from Water by Polystyrene Microspheres," IJERPH, MDPI, vol. 15(7), pages 1-15, July.

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