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25 Hydroxyvitamin D Deficiency and Its Relationship to Autoimmune Thyroid Disease in the Elderly

Author

Listed:
  • Giovanna Muscogiuri

    (I.O.S. & COLEMAN Srl, Via Alcide De Gasperi, 107,109,111, Acerra (NA) 80011, Italy)

  • Daniela Mari

    (Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy
    Geriatric Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy)

  • Silvia Prolo

    (Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy
    Geriatric Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy)

  • Letizia M. Fatti

    (Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Piazzale Brescia 20, Milan 20149, Italy)

  • Maria Celeste Cantone

    (Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy)

  • Paolo Garagnani

    (Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via San Giacomo 12, Bologna 40126, Italy
    Interdepartmental Center “L. Galvani” (C.I.G.), University of Bologna, Via San Giacomo 12, Bologna 40126, Italy)

  • Beatrice Arosio

    (Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy
    Geriatric Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, Milan 20122, Italy)

  • Carolina Di Somma

    (IRCCS SDN, Napoli Via Gianturco 113, Naples 80143, Italy)

  • Giovanni Vitale

    (Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Via Della Commenda 9/12, Milan 20122, Italy
    Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Via Zucchi 18, Cusano Milanino (MI) 20095, Italy)

Abstract

Background : Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroiditis (AT). The aim of the study was to investigate the association of AT with low 25(OH) vitamin D levels in the elderly. Methods : One hundred sixty-eight elderly subjects (mean age: 81.6 ± 9.4 years) were enrolled. Serum levels of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyroglobulin (TG-Ab) antibodies, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured. Results: The prevalence of AT was significantly higher in subjects with vitamin D deficiency (25(OH) vitamin D < 20 ng/mL) when compared with subjects with normal 25(OH) vitamin D (25(OH) vitamin D ≥ 20 ng/mL) levels (28% vs. 8%, respectively, p = 0.002). Patients with AT and vitamin D deficiency had a comparable hormonal profile compared to patients with AT and vitamin D sufficiency in terms of TSH ( p = 0.39), FT3 ( p = 0.30), FT4 ( p = 0.31), TG-Ab (0.44) and TPO-Ab (0.35). Interestingly, a significant correlation between 25(OH) vitamin D and TPO-Ab ( r = −0.27, p = 0.03) and FT3 ( r = 0.35, p = 0.006) has been found in subjects with AT while no correlation was found between 25(OH) vitamin D levels and TG-Ab ( r = −0.15, p = 0.25), TSH ( r = −0.014, p = 0.09) and FT4 ( r = 0.13, p = 0.32). Conclusions : These findings suggest that vitamin D deficiency was significantly associated with AT in the elderly. Therefore, the screening for AT should be suggested in subjects with vitamin D deficiency.

Suggested Citation

  • Giovanna Muscogiuri & Daniela Mari & Silvia Prolo & Letizia M. Fatti & Maria Celeste Cantone & Paolo Garagnani & Beatrice Arosio & Carolina Di Somma & Giovanni Vitale, 2016. "25 Hydroxyvitamin D Deficiency and Its Relationship to Autoimmune Thyroid Disease in the Elderly," IJERPH, MDPI, vol. 13(9), pages 1-7, August.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:9:p:850-:d:76791
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