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A Meta-Analysis of the Efficacy of Interferon Monotherapy or Combined with Different Nucleos(t)ide Analogues for Chronic Hepatitis B

Author

Listed:
  • Jialing Zhou

    (Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)

  • Xiaoning Wu

    (Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)

  • Wei Wei

    (Clinical Epidemiology and Evidence-Based Medicine Unit, National Clinical Research Center for Digestive Diseases, Beijing 100050, China)

  • Hong You

    (Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)

  • Jidong Jia

    (Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Clinical Epidemiology and Evidence-Based Medicine Unit, National Clinical Research Center for Digestive Diseases, Beijing 100050, China)

  • Yuanyuan Kong

    (Clinical Epidemiology and Evidence-Based Medicine Unit, National Clinical Research Center for Digestive Diseases, Beijing 100050, China)

Abstract

Background: The aim of the present study was to compare the efficacy of interferon (IFN) with or without different nucleos(t)ide analogues (NAs). Methods: The PubMed, Wan Fang and CNKI databases were searched to identify relevant trials up to May 2015. Meta-analysis was performed with Review Manager 5.0. The stability and reliability were evaluated by publication bias tests. Results: Fifty-six studies fulfilled the criteria for the meta-analysis. Compared with IFN monotherapy, combination therapy were superior in HBV DNA undetectable rate (Risk Ratio (RR) = 1.55, 95% confidence interval (CI): 1.44–1.66, p < 0.00001), HBeAg and HBsAg loss rate (RR = 1.38, 95% CI: 1.22–1.56, p < 0.00001; RR = 1.69, 95% CI: 1.03–2.78, p = 0.04, respectively) at the end of week 48 treatment. Sub-analysis showed the RRs of virological response for entecavir (ETV), adefovir (ADV), and lamivudine (LAM) were 1.64, 1.61 and 1.52, respectively; RRs of HBeAg loss rate were 1.34, 1.71 and 1.34, respectively. However, at the end of follow-up, IFN plus NAs therapy was better than IFN monotherapy only in terms of HBV DNA undetectable rate ( p = 0.0007). Conclusions: Combination therapy was better than IFN monotherapy in virological and serological responses at the end of treatment. After follow-up, only HBV DNA undetectable rate was superior for combination therapy.

Suggested Citation

  • Jialing Zhou & Xiaoning Wu & Wei Wei & Hong You & Jidong Jia & Yuanyuan Kong, 2016. "A Meta-Analysis of the Efficacy of Interferon Monotherapy or Combined with Different Nucleos(t)ide Analogues for Chronic Hepatitis B," IJERPH, MDPI, vol. 13(7), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:7:p:730-:d:74411
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    References listed on IDEAS

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    1. Qiao-Ling Xie & Ying Zhu & Ling-Hong Wu & Lin-Lin Fu & Yan Xiang, 2015. "The Efficacy and Safety of Entecavir and Interferon Combination Therapy for Chronic Hepatitis B Virus Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-19, July.
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