IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i6p582-d71895.html
   My bibliography  Save this article

Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland

Author

Listed:
  • Andrzej Prystupa

    (Department of Internal Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland)

  • Anna Błażewicz

    (Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a (Collegium Pharmaceuticum), 20-093 Lublin, Poland)

  • Paweł Kiciński

    (Department of Family Medicine, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland
    These authors contributed equally to this work.)

  • Jarosław J. Sak

    (Department of Ethics and Human Philosophy, Medical University of Lublin, Staszica 4/6 (Collegium Maximum), 20-059 Lublin, Poland
    Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
    These authors contributed equally to this work.)

  • Jarosław Niedziałek

    (Individual Medical Practice, Lublin, Ludwika Hirszfelda 5/11, 20-092 Lublin, Poland
    These authors contributed equally to this work.)

  • Wojciech Załuska

    (Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland)

Abstract

According to the WHO report, alcohol is the third most significant health risk factor for the global population. There are contrary reports about heavy metals concentrations in patients with alcoholic liver cirrhosis. The aim of this study was to investigate serum concentrations of selected heavy metals in patients with alcoholic liver cirrhosis living in the eastern part of Poland according to cirrhosis stage. The participants came from various hospitals of the Lublin region were enrolled. The study group included 46 male and 16 female patients. The control group consisted of 18 healthy individuals without liver disease. High Performance Ion Chromatography was used to determine the concentrations of metal ions (Cd, Zn, Cu, Ni, Co, Mn, and Pb) in serum samples. The concentrations of copper, zinc, nickel, and cobalt were found to be significantly lower in patients with alcoholic liver cirrhosis compared to the control group. The serum concentration of cadmium was significantly higher in patients with advanced alcoholic liver cirrhosis compared to the control group. We hypothesize that disorders of metabolism of heavy metals seem to be the outcome of impaired digestion and absorption, which are common in cirrhosis, improper diet, environmental and occupational exposure.

Suggested Citation

  • Andrzej Prystupa & Anna Błażewicz & Paweł Kiciński & Jarosław J. Sak & Jarosław Niedziałek & Wojciech Załuska, 2016. "Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland," IJERPH, MDPI, vol. 13(6), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:6:p:582-:d:71895
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/6/582/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/6/582/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Andrzej Prystupa & Paweł Kiciński & Dorota Luchowska-Kocot & Anna Błażewicz & Jarosław Niedziałek & Grzegorz Mizerski & Mariusz Jojczuk & Andrzej Ochal & Jarosław J. Sak & Wojciech Załuska, 2017. "Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis," IJERPH, MDPI, vol. 14(4), pages 1-9, April.
    2. Andrzej Prystupa & Jarosław Sak & Paweł Kiciński & Agnieszka Stenzel-Bembenek & Anna Błażewicz, 2021. "Serum Concentration of Fluoride in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland," IJERPH, MDPI, vol. 18(3), pages 1-9, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:6:p:582-:d:71895. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.