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Incidence and Mortality Risks of Cancer in Patients with Type 2 Diabetes: A Retrospective Study in Shanghai, China

Author

Listed:
  • Yunjuan Gu

    (Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong 226001, China)

  • Xuhong Hou

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
    Shanghai Diabetes Institute, Shanghai 200233, China
    Shanghai Clinical Centre of Diabetes, Shanghai 200233, China)

  • Ying Zheng

    (Department of Cancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China)

  • Chunfang Wang

    (Department of Vital Statistics, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China)

  • Lei Zhang

    (Shanghai Clinical Centre of Diabetes, Shanghai 200233, China
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China)

  • Jie Li

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
    Shanghai Diabetes Institute, Shanghai 200233, China
    Shanghai Clinical Centre of Diabetes, Shanghai 200233, China)

  • Zhezhou Huang

    (Department of Cancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China)

  • Ming Han

    (Department of Vital Statistics, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China)

  • Yuqian Bao

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
    Shanghai Diabetes Institute, Shanghai 200233, China
    Shanghai Clinical Centre of Diabetes, Shanghai 200233, China
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China)

  • Weijian Zhong

    (Vice-Director of the Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China)

  • Weiping Jia

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
    Shanghai Diabetes Institute, Shanghai 200233, China
    Shanghai Clinical Centre of Diabetes, Shanghai 200233, China
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China)

  • Shiwei Cui

    (Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong 226001, China)

Abstract

Background: Evidence from epidemiologic investigation indicates that people with type 2 diabetes (T2DM) are at a significantly higher risk of many types of cancer and mortality. The aim of this study was to investigate the incidence and mortality risks of cancer in patients with T2DM compared with the general population in Shanghai, China. Methods : Based on the Shanghai Diabetes Registry (SDR) database linking to the Shanghai Cancer Registry and Surveillance System (SCRSS), a total of 12,276 T2DM patients without cancer were defined and followed up from 1 December 2001 to 31 July 2011. Standardized incidence ratio (SIR) and standardized mortality ratio (SMR) with 95% confidence interval (CI) were calculated using the whole gender and age-matched general population of Shanghai as a reference during the same period. Results : The overall cancer risk was found higher in both males and females T2DM patients, with the SIR of 3.14 (95% CI 2.73–3.56) and 4.29 (95% CI 3.64–4.94), respectively. The overall mortality risk of cancer also significantly increased with the SMR of 2.27 (95% CI 1.86–2.68) and 1.86 (95% CI 1.46–2.26), respectively. Pancreatic cancer was with the highest SIR and SMR in both genders. Conclusions : Compared with the general population, patients with T2DM were associated with higher incidence and mortality risks of cancer, especially pancreatic cancer.

Suggested Citation

  • Yunjuan Gu & Xuhong Hou & Ying Zheng & Chunfang Wang & Lei Zhang & Jie Li & Zhezhou Huang & Ming Han & Yuqian Bao & Weijian Zhong & Weiping Jia & Shiwei Cui, 2016. "Incidence and Mortality Risks of Cancer in Patients with Type 2 Diabetes: A Retrospective Study in Shanghai, China," IJERPH, MDPI, vol. 13(6), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:6:p:559-:d:71407
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