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Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

Author

Listed:
  • Paloma I. Beamer

    (Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA
    Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
    Department of Chemical and Environmental Engineering, University of Arizona, 1133 E. James E. Rogers Way, Tucson, AZ 85721, USA)

  • Walter T. Klimecki

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, P.O. Box 210207, Tucson, AZ 85724, USA)

  • Miranda Loh

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
    Institute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK)

  • Yoshira Ornelas Van Horne

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA)

  • Anastasia J. Sugeng

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA)

  • Nathan Lothrop

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA)

  • Dean Billheimer

    (Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA
    Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA)

  • Stefano Guerra

    (Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA)

  • Robert Clark Lantz

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
    Department of Cellular and Molecular Medicine, University of Arizona, P.O. Box 245044, Tucson, AZ 85724, USA)

  • Robert A. Canales

    (Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA)

  • Fernando D. Martinez

    (Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA)

Abstract

Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil ( b = −0.43, p = 0.001, R 2 = 0.08), water ( b = −0.22, p = 0.07, R 2 = 0.03), house dust ( b = −0.37, p = 0.07, R 2 = 0.04), and dust loading ( b = −0.21, p = 0.04, R 2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels ( b = −0.42, p = 0.02, R 2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.

Suggested Citation

  • Paloma I. Beamer & Walter T. Klimecki & Miranda Loh & Yoshira Ornelas Van Horne & Anastasia J. Sugeng & Nathan Lothrop & Dean Billheimer & Stefano Guerra & Robert Clark Lantz & Robert A. Canales & Fer, 2016. "Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media," IJERPH, MDPI, vol. 13(5), pages 1-16, May.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:5:p:521-:d:70643
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    Cited by:

    1. Víctor García-Nieto & Domenico Mancini & Eva Rodríguez-Carrasco, 2016. "Normal Levels of Urinary CC16 Protein. Comments on Beamer et al. Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media. Int. J. Environ. Res. Public," IJERPH, MDPI, vol. 13(10), pages 1-3, October.
    2. Alesia Ferguson & Helena Solo-Gabriele, 2016. "Children’s Exposure to Environmental Contaminants: An Editorial Reflection of Articles in the IJERPH Special Issue Entitled, “Children’s Exposure to Environmental Contaminants”," IJERPH, MDPI, vol. 13(11), pages 1-10, November.

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