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A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans

Author

Listed:
  • Eveline Dirinck

    (Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium)

  • Alin C. Dirtu

    (Toxicology Centre, University of Antwerp, Wilrijk 2610, Belgium)

  • Govindan Malarvannan

    (Toxicology Centre, University of Antwerp, Wilrijk 2610, Belgium)

  • Adrian Covaci

    (Toxicology Centre, University of Antwerp, Wilrijk 2610, Belgium)

  • Philippe G. Jorens

    (Department of Clinical Pharmacology, Antwerp University Hospital, University of Antwerp, Edegem 2650, Belgium)

  • Luc F. Van Gaal

    (Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium)

Abstract

Background : Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (HO-PCBs) interfere with thyroid hormone action both in vitro and in vivo . However, epidemiologic studies on the link between PCB exposure and thyroid function have yielded discordant results, while very few data are available for HO-PCBs. Objectives : Our study aimed at investigating the relationship between clinically available markers of thyroid metabolism and serum levels of both PCBs and HO-PCBs. Subjects and Methods : In a group of 180 subjects, thyroid-stimulating hormone (TSH) and free thyroxin (fT4), 29 PCBs (expressed both in lipid weight and in wet weight) and 18 HO-PCBs were measured in serum. Results : In regression models, adjusted for gender, age, current smoking behavior, BMI and total lipid levels, serum levels of 3HO-PCB118 and 3HO-PCB180, and PCB95 lw , PCB99 lw and PCB149 lw were independent, significant predictors of fT4. A stepwise, multiple regression with gender, age, current smoking behavior, BMI and total lipid levels and all five previously identified significant compounds retained age, BMI, PCB95 lw , PCB99 lw and 3HO-PCB180 as significant predictors of fT4. TSH levels were not predicted by serum levels of any of the PCBs or HO-PCBs. Conclusions : Our study indicates that in vivo , circulating fT4 levels can be linked to serum levels of several PCBs and hydroxylated PCB metabolites.

Suggested Citation

  • Eveline Dirinck & Alin C. Dirtu & Govindan Malarvannan & Adrian Covaci & Philippe G. Jorens & Luc F. Van Gaal, 2016. "A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans," IJERPH, MDPI, vol. 13(4), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:4:p:421-:d:68168
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    Cited by:

    1. Petra Maria Gaum & Monika Gube & André Esser & Thomas Schettgen & Natalia Quinete & Jens Bertram & Franziska Maria Putschögl & Thomas Kraus & Jessica Lang, 2019. "Depressive Symptoms After PCB Exposure: Hypotheses for Underlying Pathomechanisms via the Thyroid and Dopamine System," IJERPH, MDPI, vol. 16(6), pages 1-18, March.

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