Author
Listed:
- Qing-Jie Chen
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China
These authors contributed equally to this work.)
- Hong-Mei Lai
(Department of Cardiology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
These authors contributed equally to this work.)
- Bang-Dang Chen
(Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China
Clinical Research Institute of Xinjiang Medical University, Urumqi 830054, China)
- Xiao-Mei Li
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Hui Zhai
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Chun-Hui He
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Shuo Pan
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Department of Cardiology, People’s Hospital of Shaanxi Province, Xian 710000, China)
- Jun-Yi Luo
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Jing Gao
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Fen Liu
(Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China
Clinical Research Institute of Xinjiang Medical University, Urumqi 830054, China)
- Yi-Tong Ma
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
- Yi-Ning Yang
(Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)
Abstract
Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.
Suggested Citation
Qing-Jie Chen & Hong-Mei Lai & Bang-Dang Chen & Xiao-Mei Li & Hui Zhai & Chun-Hui He & Shuo Pan & Jun-Yi Luo & Jing Gao & Fen Liu & Yi-Tong Ma & Yi-Ning Yang, 2016.
"Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China,"
IJERPH, MDPI, vol. 13(2), pages 1-12, February.
Handle:
RePEc:gam:jijerp:v:13:y:2016:i:2:p:235-:d:64122
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