IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i2p224-d63988.html
   My bibliography  Save this article

Environmental Exposure to Triclosan and Semen Quality

Author

Listed:
  • Wenting Zhu

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    These authors contributed equally to this work.)

  • Hao Zhang

    (MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai 200032, China
    These authors contributed equally to this work.)

  • Chuanliang Tong

    (Department of Science and Research, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China)

  • Chong Xie

    (Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China)

  • Guohua Fan

    (Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China)

  • Shasha Zhao

    (MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China)

  • Xiaogang Yu

    (MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China)

  • Ying Tian

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China)

  • Jun Zhang

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China)

Abstract

Triclosan (2,4,4′-trichloro-2′-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine) −1 (interquartile range, 0.41–2.95 ng (mg·creatinine) −1 ). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient β = −0.17; 95% confidence interval (CI) (−0.32, −0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (β = −0.35; 95% CI (−0.68, −0.03)), percentage of sperms with normal morphology (β = −1.64; 95% CI (−3.05, −0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings.

Suggested Citation

  • Wenting Zhu & Hao Zhang & Chuanliang Tong & Chong Xie & Guohua Fan & Shasha Zhao & Xiaogang Yu & Ying Tian & Jun Zhang, 2016. "Environmental Exposure to Triclosan and Semen Quality," IJERPH, MDPI, vol. 13(2), pages 1-12, February.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:2:p:224-:d:63988
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/2/224/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/2/224/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:2:p:224-:d:63988. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.