Author
Listed:
- Anna Jurczak
(Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland)
- Małgorzata Szkup
(Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland)
- Anna Grzywacz
(Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego 26, 71-460 Szczecin, Poland)
- Krzysztof Safranow
(Department of Biochemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)
- Elżbieta Grochans
(Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, Poland)
Abstract
The objective of this work was the analysis of the relationships between the genotypes of the AMH and AMH receptor type 2 genes, hormone levels and the menstrual cycle in a group of Polish women in the late reproductive stage. The study was conducted using a measurement-based method (body weight and height), laboratory method (serum hormone levels AMH, FSH and E2), and genetic analysis (DNA isolated from whole blood by a salting-out method). The study involved 345 healthy, late-reproductive-stage women from Poland, aged 42.3 ± 4.5 years. The analysis demonstrated that neither the T/T and G/T+G/G genotypes of the AMH Ile 49 Ser polymorphism (rs10407022), nor the A/A and the G/A + G/G genotypes of the AMHR2 2482 A > G polymorphism (rs2002555), nor the C/C and C/T + T/T genotypes of the AMH polymorphism (rs11170547) were statistically significantly related ( p > 0.05) to such factors as age, BMI, hormone (FSH and E 2 ) levels and ovarian parameters (AMH) in the follicular phase. No relationships were found between ovarian parameters (FSH, E 2 , AMH) and genetic variants of AMH (rs10407022) and AMHR2 (rs11170547, rs2002555) in healthy women in the late reproductive stage.
Suggested Citation
Anna Jurczak & Małgorzata Szkup & Anna Grzywacz & Krzysztof Safranow & Elżbieta Grochans, 2016.
"The Relationship between AMH and AMHR2 Polymorphisms and the Follicular Phase in Late Reproductive Stage Women,"
IJERPH, MDPI, vol. 13(2), pages 1-7, February.
Handle:
RePEc:gam:jijerp:v:13:y:2016:i:2:p:185-:d:63333
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