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Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers

Author

Listed:
  • Feng Xiong

    (Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Qin Li

    (Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Bo Zhou

    (Research Center for Regenerative Medicine, Guangxi Medical University, Nanning 530021, China)

  • Jiongli Huang

    (Atmospheric Environment Research Center, Scientific Research Academy of Guangxi Environmental Protection, Nanning 530021, China)

  • Guiqiang Liang

    (Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Li’e Zhang

    (Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Shuyan Ma

    (Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Li Qing

    (Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Linhan Liang

    (Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Jing Su

    (Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China)

  • Xiaowu Peng

    (Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China)

  • Qin Li

    (Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China)

  • Yunfeng Zou

    (Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China)

Abstract

Atmospheric benzene, toluene, ethylbenzene, and xylenes (BTEX) can lead to multiple health injuries. However, what remains uncertain is the effect of long-term exposure to low levels of BTEX. Thus, we determined the BTEX levels in the air from the refueling and office areas in gas stations. Then we collected workers’ (200 refueling vs. 52 office workers) peripheral blood samples to analyze the serum total-superoxide dismutase (T-SOD), glutathione (GSH), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) levels. DNA damage was analyzed by the comet assay and micronucleus test in buccal epithelial cells. We found that the levels of BTEX in refueling areas were significantly higher than those in office areas ( p < 0.001). The serum T-SOD and GSH of refueling workers were significantly lower than those in office workers ( p < 0.001). By contrast, the serum MDA and 8-OHdG of refueling workers were significantly higher than those of office workers ( p < 0.001, MDA; p = 0.025, 8-OHdG). Furthermore, tail and Olive tail moments in refueling workers were longer ( p = 0.004, tail moment; p = 0.001, Olive tail moment), and the micronucleus rate was higher ( p < 0.001) than those in office workers. Taken together, long-term exposure to low levels of BTEX may reduce the antioxidant ability and increase the risk of DNA damage in refueling workers of gas stations.

Suggested Citation

  • Feng Xiong & Qin Li & Bo Zhou & Jiongli Huang & Guiqiang Liang & Li’e Zhang & Shuyan Ma & Li Qing & Linhan Liang & Jing Su & Xiaowu Peng & Qin Li & Yunfeng Zou, 2016. "Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers," IJERPH, MDPI, vol. 13(12), pages 1-9, December.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:12:p:1212-:d:84550
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    Cited by:

    1. Juexiu Li & Hongbo Zhang & Diwen Ying & Yalin Wang & Tonghua Sun & Jinping Jia, 2019. "In Plasma Catalytic Oxidation of Toluene Using Monolith CuO Foam as a Catalyst in a Wedged High Voltage Electrode Dielectric Barrier Discharge Reactor: Influence of Reaction Parameters and Byproduct C," IJERPH, MDPI, vol. 16(5), pages 1-14, February.

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