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Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

Author

Listed:
  • Lilija Kovalchuka

    (Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia)

  • Svetlana Cvetkova

    (Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia)

  • Julija Trofimova

    (Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia)

  • Jelena Eglite

    (Laboratory of Clinical Immunology and Immunogenetic, Riga Stradiņš University, Riga LV-1067, Latvia)

  • Sandra Gintere

    (Department of Family Medicine, Riga Stradiņš University, Riga LV-1067, Latvia)

  • Irina Lucenko

    (Centre for Disease Prevention and Control of Latvia, Riga LV-1005, Latvia)

  • Barbara Oczko-Grzesik

    (Department of Infectious Diseases, Medical University of Silesia, 40-055 Katowice, Poland)

  • Ludmila Viksna

    (Department of Infectology and Dermatology, Riga Stradiņš University, Riga LV-1006, Latvia)

  • Angelika Krumina

    (Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia
    Department of Infectology and Dermatology, Riga Stradiņš University, Riga LV-1006, Latvia)

Abstract

The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

Suggested Citation

  • Lilija Kovalchuka & Svetlana Cvetkova & Julija Trofimova & Jelena Eglite & Sandra Gintere & Irina Lucenko & Barbara Oczko-Grzesik & Ludmila Viksna & Angelika Krumina, 2016. "Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis," IJERPH, MDPI, vol. 13(12), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:12:p:1194-:d:84233
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