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Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat

Author

Listed:
  • Yingbo Li

    (Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
    These authors contributed equally to this work.)

  • Yan Wang

    (Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
    These authors contributed equally to this work.)

  • Liu Tu

    (Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China)

  • Di Chen

    (Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China)

  • Zhi Luo

    (Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China)

  • Dengyuan Liu

    (Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China)

  • Zhuang Miao

    (Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China)

  • Gang Feng

    (Pediatric Specialty of Clinical Medicine, Academy of Pediatrics, Chongqing Medical University, Chongqing 400016, China)

  • Li Qing

    (The First Clinical College of Chongqing Medical University, Chongqing 400016, China)

  • Shali Wang

    (Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China)

Abstract

Graphene oxide (GO) is an oxidized derivative of graphene used in biotechnology and medicine. The safety of GO is uncertain, so we evaluated its toxicity in male rats. Rat tail veins were injected with 2.5, 5, or 10 mg/kg GO for seven days and behavioral patterns, pathology, and tissue morphology were assessed. Data show that behaviors were not altered according to an open field test and a functional observational battery test, but histopathological analysis indicated that GO caused inflammation of the lung, liver, and spleen. GO also reduced cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). No other organs were modified. Thus, high concentrations of GO are toxic for the lung, liver, and spleen, but the mechanism by which this occurs requires more study.

Suggested Citation

  • Yingbo Li & Yan Wang & Liu Tu & Di Chen & Zhi Luo & Dengyuan Liu & Zhuang Miao & Gang Feng & Li Qing & Shali Wang, 2016. "Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat," IJERPH, MDPI, vol. 13(11), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1149-:d:83113
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    Cited by:

    1. Zaida Zainal & Augustine Ong & Choo Yuen May & Sui Kiat Chang & Afiqah Abdul Rahim & Huzwah Khaza’ai, 2020. "Acute and Subchronic Oral Toxicity of Oil Palm Puree in Sprague–Dawley Rats," IJERPH, MDPI, vol. 17(10), pages 1-18, May.
    2. Qin Wang & Yi Zhu & Bin Song & Rong Fu & Yanfeng Zhou, 2022. "The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles in Caenorhabditis elegans," IJERPH, MDPI, vol. 19(7), pages 1-13, March.

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