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The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Author

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  • Jin Yan

    (Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
    The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
    These authors contributed equally to this work.)

  • Qiang She

    (The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
    Department of Gastroenterology, Yangzhou NO.1 People’s Hospital, Yangzhou 225001, China
    These authors contributed equally to this work.)

  • Yifeng Zhang

    (Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
    The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
    These authors contributed equally to this work.)

  • Chang Cui

    (The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
    Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China)

  • Guoxin Zhang

    (Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
    The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China)

Abstract

Arrhythmia is a common disease around the world and Helicobacter pylori ( H. pylori ) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori . We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori . In the arrhythmia group, 392 (58.1%) were H. pylori -positive and in the control group 640 (47.8%) were H. pylori -positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081–2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.

Suggested Citation

  • Jin Yan & Qiang She & Yifeng Zhang & Chang Cui & Guoxin Zhang, 2016. "The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies," IJERPH, MDPI, vol. 13(11), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1139-:d:83023
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    References listed on IDEAS

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    1. Mingjia Xiao & Yiming Wang & Yi Gao, 2013. "Association between Helicobacter pylori Infection and Pancreatic Cancer Development: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
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