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l -Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

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  • Heran Ma

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

  • Yudan Ma

    (Sports Science Research Institute of Jilin Province, Changchun 130022, China)

  • Zhixian Zhang

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

  • Ziyuan Zhao

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

  • Ran Lin

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

  • Jinming Zhu

    (The China-Japan Union Hospital of Jilin University, Changchun 130033, China)

  • Yi Guo

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

  • Li Xu

    (Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China)

Abstract

The antioxidant properties of l -arginine ( l -Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans , a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l -Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l -Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.

Suggested Citation

  • Heran Ma & Yudan Ma & Zhixian Zhang & Ziyuan Zhao & Ran Lin & Jinming Zhu & Yi Guo & Li Xu, 2016. "l -Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans," IJERPH, MDPI, vol. 13(10), pages 1-9, September.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:10:p:969-:d:79522
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    Cited by:

    1. Marcia G. Ory & Matthew Lee Smith, 2017. "What If Healthy Aging Is the ‘New Normal’?," IJERPH, MDPI, vol. 14(11), pages 1-5, November.

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